摘要
目的 探讨莫西沙星与四联抗结核药物联合治疗对难治性结核性脑膜炎的临床治疗效果。方法 将107例难治性结核性脑膜炎患者随机分为观察组(54例)和对照组(53例),2组患者给予对症支持治疗和四联抗结核药物治疗,观察组在此基础上给予莫西沙星治疗,2组均治疗3个月。观察2组疗效,检测脑脊液白细胞数、葡萄糖、氯化物、蛋白质、压力以及神经元特异性烯醇化酶(NSE)、神经生长因子(NGF)等指标水平。结果 观察组总有效率(51例,94.44%)高于对照组(42例,79.25%),治疗后脑脊液白细胞数(11.94±2.70)×10^6个/L、蛋白质(0.70±0.18)g/L、压力(142.37±28.79)mmH 2O以及NSE(12.54±2.52)mg/L、NGF(16.70±3.57) ng/L低于对照组,而葡萄糖(2.94±0.72)mmol/L和氯化物(137.40±35.10) mmol/L则高于对照组,差异均有统计学意义(P<0.05)。结论 莫西沙星与四联抗结核药物联合治疗可改善难治性结核性脑膜炎患者脑脊液相关指标水平,有效提高治疗效果,促进神经系统功能的恢复。
Objective To explore the clinical therapeutic effect of moxifloxacin and quadruple anti tuberculosis drugs in patients with refractory tuberculous meningitis. Methods 107 patients with refractory tuberculous meningitis were selected as research object and randomly divided into observation group (54 cases) and control group (53 cases).The two groups were given symptomatic supportive therapy and quadruple anti tuberculosis drugs.The observation group was given moxifloxacin on the basis of the above treatment.Both groups were treated for 3 months.The efficacy of the two groups was observed,and the levels of white blood cells,glucose,chloride,protein,stress,neuron specific enolase (NSE) and nerve growth factor (NGF) of cerebrospinal fluid were were measured. Results The total effective rate in the observation group (51 cases,94.44%) was significantly higher than the control group (42 cases,79.25%)(P<0.05).The levels of white blood cells (11.94±2.70)×10^6/L,protein (0.70±0.18) g/L,pressure (142.37±28.79) mmH 2O,NSE (12.54±2.52) mg/L and NGF (16.70±3.57) ng/L of cerebrospinal fluid in the observation group were significantly lower than the control group after treatment (P<0.05),while the levels of glucose (2.94±0.72) mmol/L and chloride (137.40±35.10) mmol/L were significantly higher than the control group (P<0.05). Conclusion The combination of moxifloxacin and quadruple anti tuberculosis drugs could improve the indicators of cerebrospinal fluid in patients with refractory tuberculous meningitis,effectively improve the therapeutic effect and promote the recovery of nervous system function.
作者
宋中立
SONG Zhongli(The Sixth People's Hospital of Zhengzhou,Zhengzhou 450000,China)
出处
《中国实用神经疾病杂志》
2019年第8期880-885,共6页
Chinese Journal of Practical Nervous Diseases
关键词
难治性结核性脑膜炎
抗结核药物
莫西沙星
脑脊液
Refractory tuberculous meningitis
Anti tuberculosis drugs
Moxifloxacin
Cerebrospinal fluid
