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清远市连南地区瑶族人群HLA-B*1502基因表达分析

Analysis of the gene expression of HLA-B*1502 in the population of Yao nationality in Liannan area of Qingyuan city
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摘要 目的 探讨连南地区瑶族遗传背景下HLA-B *1502基因的分布频率。方法 选取2016年1月至2018年10月在连南瑶族自治县人民医院住院的805例患者为研究对象。采用实时定量聚合酶链反应检测患者HLA-B *1502的表达,比较瑶族人群和非瑶族人群HLA-B *1502基因阳性率、基因频率,分析影响瑶族人群HLA-B *1502基因阳性率的因素。结果 广东省清远市连南地区瑶族人群HLA-B *1502基因阳性率为 13.39 %,基因频率为0.103;而非瑶族人群的HLA-B *1502基因阳性率为16.35%,基因频率为0.123。两组患者的HLA-B *1502基因阳性率比较,差异无统计学意义(χ 2=1.079, P =0.299)。HLA-B *1502阳性的瑶族患者的平均年龄为(51.63±17.87)岁,明显高于HLA-B *1502阴性的瑶族患者的平均年龄[(47.07± 20.92 )岁, t = 2.187, P =0.029]。结论 广东省清远市连南地区瑶族人群HLA-B *1502基因频率为0.103,且HLA-B *1502携带情况与年龄存在一定关系。 Objective To study the frequency of HLA-B *1502 in the population of Yao nationality in Liannan area of Qingyuan city in Guangdong province. Methods A total of 805 patients in People′s Hospital of Liannan Yao Autonomous County from January 2016 to October 2018 were involved in this study.Real-time PCR was employed to assess the expression of HLA-B *1502 in patients.The gene positive ratio and frequency of HLA-B *1502 were calculated and compared between Yao nationality population and non-Yao nationality population.And impact factors of the positive ratio of HLA-B *1502 in the population of Yao nationality were analyzed. Results The positive ratio of HLA-B *1502 in the population of Yao nationality in Liannan area of Qingyuan city was 13.39%,and its frequency was 0.103.However,the positive ratio in non-Yao nationality group was 16.35% and its frequency was 0.123.There was no different on positive ratio of HLA-B *1502 between the two groups ( P >0.05).The average age of patients with positive HLA-B *1502 was (51.63± 17.87 ) years old,which was obviously higher than (47.07±20.92) years old in patients with negative HLA-B *1502 ( t =2.187, P =0.029). Conclusion The gene frequency of HLA-B *1502 in the population of Yao nationality in Liannan area of Qingyuan city is 0.103.The positive ratio of HLA-B *1502 associated with patients′ age.
作者 孔韦东 黄振勇 成丽英 潘秀静 罗永钊 唐亚吊 刘倩 陈梅芳 钟文君 KONG Weidong;HUANG Zhenyong;CHENG Liying;PAN Xiujing;LUO Yongzhao;TANG Yadiao;LIU Qian;CHEN Meifang;ZHONG Wenjun(Department of Clinical Laboratory,People′s Hospital of Liannan Yao Autonomous County,Qingyuan,Guangdong 513300,China;Molecular Diagnostic Center,Qingyuan People′sHospital,Qingyuan,Guangdong 511518,China)
机构地区 连南瑶族自治县人民医院检验科 清远市人民医院分子诊断中心
出处 《检验医学与临床》 CAS 2019年第12期1721-1723,共3页 Laboratory Medicine and Clinic
关键词 瑶族 HLA-B *1502 基因频率 Yao nationality HAL-B *1502 gene frequency
分类号 R446.9 [医药卫生—诊断学]
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检验医学与临床
2019年 第12期

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