摘要
创伤性颅脑损伤(TBI)是发病率高且致死、致残率高的疾病之一,严重危害人类健康。TBI所致原发性及继发性脑损伤是多种病理生理机制相互作用的瀑布式级联反应,因其损伤因素多且机制复杂,故目前TBI的治疗手段及治疗效果有限。近年来,动物实验和临床研究结果证实干细胞治疗可在一定程度上缓解TBI介导的神经损伤。因此,激活内源性神经干细胞(NSCs)和(或)外源性干细胞移植治疗可能是TBI治疗的新策略。本文围绕TBI后NSCs激活及外源性干细胞移植治疗TBI的研究进展进行综述,着重探讨外源性干细胞移植治疗TBI的作用及可能机制。
Traumatic brain injury (TBI) is one of the diseases with high morbidity, mortality, and disability, which seriously endangers human health. Primary and secondary injuries caused by TBI are cascade reaction of various pathophysiological interactions. Because of its many injury factors and complex mechanisms, the treatment and therapeutic effect of TBI are limited at present. In recent years, animal experiments and clinical studies have shown that stem cell therapy could alleviate TBI-mediated neurological damage to a certain extent. Therefore, activation of endogenous neural cells response and transplantation of exogenous stem cells may be new strategies for TBI treatment. This article reviews the research progress of activation of endogenous neural cells response and transplantation of exogenous stem cells after TBI, and focuses on the therapeutic effects and possible mechanisms of stem cell transplantation in TBI treatment.
作者
张吉
张小军
姜栩恒
黄晓飞
谢方可
刘思佳
孙田静
葛红飞
喻安永
Zhang Ji;Zhang Xiaojun;Jiang Xuheng;Huang Xiaofei;Xie Fangke;Liu Sijia;Sun Tianjing;Ge Hongfei;Yu Anyong(Emergency Department,Affiliated Hospital of Zunyi Medical University,Zunyi 563000,China;Department of Neurosurgery,Southwest Hospital,Army Medical University,Chongqing 400038,China)
出处
《中华神经医学杂志》
CAS
CSCD
北大核心
2019年第6期634-638,共5页
Chinese Journal of Neuromedicine
基金
国家自然科学基金(81560217)
遵义医科大学急诊医学研究生工作站(GZZ2017006).
关键词
创伤性颅脑损伤
干细胞
神经再生
细胞移植
Traumatic brain injury
Stem cell
Neural regeneration
Cell transplantation
