摘要
目的探究丁苯酞在急性脑梗死患者中的疗效与安全性。方法选取2017年5月~2018年6月于某院治疗的急性脑梗死患者100例,按治疗方法将患者分为对照组和试验组,每组各50例。对照组患者给予常规治疗,试验组在给予常规治疗基础上口服丁苯酞0.2 g·d^-1。结果分析比较两组患者治疗后的临床疗效,试验组的总有效率明显优于对照组,比对照组高20%;分析比较两组患者治疗前后的NIHSS评分,治疗后试验组的降低程度明显优于对照组;分析比较两组患者治疗前后的Barthel指数评分,治疗后试验组的提高程度明显优于对照组;且以上差异均具有统计学意义(P<0.05)。对丁苯酞在急性脑梗死患者治疗中的安全性分析,两组患者的各项身体指标均在正常范围之内。在临床治疗过程中,试验组和对照组均出现了极少数的不良反应情况,经对症治疗,情况已有所好转,且患者发生不良反应的情况在正常范围之内。结论丁苯酞可以治疗急性脑梗死患者的神经功能以及各种临床症状得到明显改善,并且具有良好的用药安全性,建议在临床治疗过程中广泛使用。
OBJECTIVE To investigate the efficacy and safety of butylphthalide in patients with acute cerebral infarction.METHODS 100 patients with acute cerebral infarction treated in a hospital from May 2017 to June 2018 were selected.The patients were divided into control group and experimental group according to the treatment method,50 cases in each group. The control group received routine treatment,and the experimental group received oral butylphthalide 0.2g·d^-1 on the basis of conventional treatment.RESULTS The clinical efficacy of the two groups of patients after treatment was analyzed and compared.The total effective rate of the experimental group was significantly better than that of the control group,which was 20% higher than that of the control group. The NIHSS scores and the Barthel index scores before and after treatment were compared between the two groups.The improvement of the test group was significantly better than that of the control group after treatment(P<0.05). The safety of butylphthalide in the treatment of patients with acute cerebral infarction,the physical indicators of the two groups of patients were within the normal range.In the course of clinical treatment,there were very few adverse reactions in the test group and the control group.After symptomatic treatment,the situation has improved,and the patient ’s adverse reactions were within the normal range. CONCLUSION Butylphthalide can improve the neurological function and various clinical symptoms of patients with acute cerebral infarction,and has good drug safety.It is recommended to be widely used in clinical treatment.
作者
巴雪
刘烨妹
BA Xue;LIU Yemei(Department of Pharmacy, Shengjing Hospital Affiliated of China Medical University, Shenyang, Liaoning110004, China)
出处
《今日药学》
CAS
2019年第5期321-324,共4页
Pharmacy Today
关键词
丁苯酞
急性脑梗死
疗效
安全性
butylphthalide
acute cerebral infarction
efficacy
safety
