摘要
目的探讨C-反应蛋白(CRP)在急性一氧化碳中毒后的变化及其预测迟发性脑病的价值。方法选取本院近三年108例收治的急性一氧化碳中毒患者,按程度分为轻度中毒组(52例),中度中毒组(24例),重度中毒组(32例)。比较入院第1d、3d、5d组间患者CRP值;并按照CRP值将其分为CRP正常组(40例),CRP轻度升高组(32例),CRP重度升高组(36例),随访其迟发性脑病发生情况。结果入院第1d,轻、中度中毒组CRP值与重度中毒组差异均具有统计学意义(P<0.05)。就诊后3d,重度中毒组CRP值高于轻、中度中毒组,中度中毒组患者CRP值高于轻度中毒组患者,差异均具有统计学意义(P<0.05)。入院第5d,重度中毒组CRP值高于轻、中度中毒组患者(P<0.05),其余组间差异无统计学意义。重度一氧化碳中毒患者,C-反应蛋白数值明显升高。CRP值与急性一氧化碳中毒预后的迟发性脑病存在正相关(r=0.457, P<0.01);其预测急性一氧化为预测迟发性脑病的监测指标之一,且其灵敏度较高,有一定的特异性,在预测与诊治一氧化碳中毒并迟发性脑病患者时有一定的临床价值。
Objective To investigate the changes of C-reactive protein(CRP) after acute carbon monoxide poisoning and its correlation in predicting delayed encephalopathy.Methods:The patients with acute carbon monoxide poisoning admitted to our hospital in the past three years were divided into the mild poisoning group(52 cases),the moderate poisoning group(24 cases) and the severe poisoning group(32 cases).The CRP values of patients between 1 d,3 d and 5 d after treatment were compared.According to CRP,they were divided into the CRP normal group(40 cases),the CRP mildly elevated group(32 cases) and the CRP severely elevated group(36 cases),which follow-up of the occurrence of delayed encephalopathy.Results:At 1 day after treatment,the CRP values in the mild and moderate poisoning group were significantly different from those in the severe poisoning group(P<0.05).At 3 days after treatment,the CRP value of the severe poisoning group was higher than that of the mild and the moderate poisoning group.The CRP value of the moderate poisoning group was higher than that of the mild poisoning group,and the difference was statistically significant(P<0.05).At 5 days after treatment,the CRP value in the severe poisoning group was higher than that of the mild and moderate poisoning group(P<0.05),and the difference between the other groups was not statistically significant.As the degree of carbon monoxide poisoning increases,the patient’s CRP value gradually increases.In patients with severe carbon monoxide poisoning,the C-reactive protein value was significantly increased.The CRP value was positively correlated with the delayed encephalopathy of acute carbon monoxide poisoning(r=0.457,P<0.01).The sensitivity of predicting delayed onset encephalopathy in acute carbon monoxide poisoning was 93.33% and the specificity was 41.94%.Conclusion:CRP can be used as one of the monitoring indicators for predicting delayed encephalopathy,and the sensitivity is high,which has certain clinical value in the treatment of patients with carbon monoxide poisoning.
作者
张振贵
景建军
俞作发
杨翌承
李剑峰
汪学琴
梁彦平
何光辉
ZHANG Zhen gui;JING Jian jun;YU Zuo fa;Yang Yi cheng;LI Jian feng;WANG Xue qin;LIANG Yan ping;HE Guang hui(Shihezi People's Hospital Emergency Center,Shihezi,Xinjiang 832000,China)
出处
《新疆医学》
2019年第3期244-247,共4页
Xinjiang Medical Journal
基金
新疆维吾尔自治区石河子市卫生科研项目(项目编号:2017HZ17)
关键词
急性一氧化碳中毒
C-反应蛋白
预后
迟发性脑病
Acute Carbon Monoxide Poisoning
C-reactive Protein
Prognosis
Delayed Encephalopathy
