摘要
目的:研究血清生化指标水平与冠脉粥样硬化严重程度的关系,为临床诊断及治疗提供参考。方法:选择本院2012年4月至2016年11月期间收治的冠脉粥样硬化患者160例,根据斑块性质,患者被分为稳定斑块组(80例)和不稳定斑块组(80例),另选择同期健康体检者60例作为健康对照组。测量比较三组血清生化指标水平,分析其与冠脉粥样硬化严重程度的关系。结果:随着冠状动脉粥样硬化程度的加重,血清转化生长因子(TGF)-β、肿瘤坏死因子(TNF)-α、核转录因子(NF)-κB、血管内皮细胞生长因子(VEGF)、重组牛碱性成纤维细胞生长因子(bFGF)、单核细胞趋化蛋白(MCP)-1、基质细胞衍生因子(SDF)-1、趋化因子受体CXCR-4、趋化因子受体(CCR)-2、参与TGF-β超家族蛋白信号传导的相关蛋白(Smad)-1、Smad-2、Smad-3、过氧化物酶体增殖物激活受体(PPAR)-γ、基质金属蛋白酶组织抑制剂(TIMP)-1、TIMP-2、TIMP-3水平逐渐升高,健康对照组<稳定斑块组<不稳定斑块组,两两比较均有显著差异,P均=0.001。与健康对照组比较,稳定斑块组和不稳定斑块组血清半胱氨酸天冬氨酸酶(Caspase)-3、Caspase-6、BCL-2相关X蛋白(Bax)水平均显著升高,Bcl2水平显著降低,P均=0.001。结论:TGF-β、MCP-1及CXCR-4蛋白等生化指标与冠状动脉粥样硬化的严重程度密切相关,可作为临床治疗的重要指标。
Objective:To explore relationship between serum biomarker levels and severity of coronary atherosclerosis (CAS), and provide reference for diagnosis and treatment. Methods:A total of 160 CAS patients treated in our hospital from Apr 2012 to Nov 2016 were selected. According to plaque characteristics, patients were divided into stable plaque group (n=80) and unstable plaque group (n=80), another 60 healthy subjects undergoing physical examination simultaneously were selected as healthy control group. Serum biomarker levels were measured and compared among three groups, and their relationship with CAS severity were analyzed. Results:Along with CAS aggravated, there were gradual rise in serum levels of trasforming growth factor (TGF)-β, tumor necrosis factor (TNF)-α, nuclear factor (NF)-κB, vascular endothelial growth factor (VEGF), recombinant bovine basic fibroblast growth factor (bFGF), monocyte chemoattractant protein (MCP)-1, stroma-cell derivated factor (SDF)-1, chemokine receptor(CXCR)-4, chemokine receptor (CCR)-2, Smad-1, Smad-2, Smad-3, peroxisome proliferators-activated receptor (PPAR)-γ, tissue inhibitor of metalloproteinase (TIMP)-1, TIMP-2, TIMP-3, healthy control group< stable plaque group< unstable plaque group, there existed significant difference between any two groups, P =0.001 all. Compared with healthy control group, there were significant rise in serum levels of Caspase-3, Caspase-6 and Bcl-2 related X protein (Bax), and significant reduction in Bcl2 level in stable and unstable plaque group, P =0.001 all. Conclusion:Biomarkers, such as TGF-β, MCP-1, CXCR-4 etc., are closely associated with severity of coronary atherosclerosis, which can be used as important indexes for clinical treatment.
作者
刘彦辉
LIU Yan-hui(Department of Cardiology, People′s Hospital of Jinzhou City, Jinzhou, Hebei, 052260, China)
出处
《心血管康复医学杂志》
CAS
2019年第3期310-315,共6页
Chinese Journal of Cardiovascular Rehabilitation Medicine
