摘要
目的:探讨动态监测中性粒细胞/淋巴细胞比值(NLR)在早期新生儿缺氧缺血性脑病(HIE)病情评估中的应用价值。方法:选取我院HIE患儿86例(2016年11月至2018年10月)设为研究组,另选取同期正常新生儿86例设为对照组。所有新生儿娩出后第1d、第3天及第7天分别抽取血液样本2mL,经全自动血细胞分析仪检测中性粒细胞值及淋巴细胞值,并计算NLR。统计分析研究组与对照组、研究组不同病情程度患儿娩出后第1天、第3天及第7天中性粒细胞值及淋巴细胞值、NLR,并统计分析中性粒细胞值及淋巴细胞值、NLR与HIE病情程度关联性。结果:娩出后第1天、第3天研究组中性粒细胞值及NLR高于对照组(P<0.05),淋巴细胞值与对照组间无显著差异(P>0.05),娩出后第7天研究组中性粒细胞值及淋巴细胞值、NLR与对照组间无显著差异(P>0.05);娩出后第1天、第3天中重度HIE患儿中性粒细胞值及NLR高于轻度HIE患儿(P<0.05),淋巴细胞值与轻度HIE患儿间无显著差异(P>0.05),娩出后第7天中重度HIE患儿中性粒细胞值及淋巴细胞值、NLR与轻度HIE患儿间无显著差异(P>0.05);经Spearman分析可知,中性粒细胞值(r=0.801)及NLR(r=0.796)与HIE病情程度间存在显著正相关关系(P<0.05),淋巴细胞值(r=0.467)与HIE病情程度间无明显相关性(P>0.05)。结论:HIE患儿娩出后前3d中性粒细胞值及NLR异常增高,且其增高幅度随病情加剧而增大,两者间存在显著正相关关系,临床可通过动态监测NLR评估HIE病情程度,为临床制定、调整治疗方案提供一定参考依据。
Objective: To investigate the value of dynamic monitoring of neutrophil/lymphocyte ratio (NLR) in the assessment of early neonatal hypoxic ischemic encephalopathy (HIE). Methods: 86 children with HIE in our hospital (November 2016-October 2018) were enrolled in the study group, and 86 normal newborns were selected as the control group. All the newborns were given 2 ml of blood samples on the 1st, 3rd and 7th day after delivery, and the neutrophil and lymphocyte values were detected by automatic blood cell analyzer, and NLR was calculated. Statistically analyze the neutrophil value, lymphocyte value, NLR, and statistical analysis of neutrophil values and lymphocytes on the 1st, 3rd and 7th day after delivery in the study group and the control group and the study group. Cell values, NLR and HIE severity were correlated. Results: The neutrophil value and NLR of the study group were higher than those of the control group on the 1st and 3rd day after delivery (P<0.05). There was no significant difference between the lymphocyte values and the control group and the 7th day after delivery (P>0.05). There were no significant differences in neutrophil value and lymphocyte value, NLR between the study group and control group (P>0.05). The neutrophil value and NLR were higher in children with severe HIE on the 1st and 3rd day after delivery.(P<0.05). There was no significant difference among lymphocyte values in children with mild HIE (P>0.05), neutrophil value and lymphocyte value, NLR in children with severe HIE on the 7th day after delivery. There was no significant difference among children with mild HIE (P>0.05). Spearman's test showed that there was a significant positive correlation between neutrophil value (r=0.801) and NLR (r=0.796) and HIE severity (P<0.05), there was no significant correlation between lymphocyte values (r=0.467) and HIE severity (P>0.05). Conclusion: The neutrophil value and NLR abnormality increase in the first 3 days after delivery of HIE children, and the increase rate increases with the severity of the disease. There is a significant positive correlation between the two, and the clinical manifestation of HIE can be assessed by dynamic monitoring of NLR, providing a reference for clinical development and adjustment of treatment plans.
作者
温晓芳
WEN Xiaofang(Zhongshan Hospital of Traditional Chinese Medicine, Guangdong Zhongshan 528400, China)
出处
《河北医学》
CAS
2019年第6期927-931,共5页
Hebei Medicine
基金
广东省自然科学基金资助项目,(编号:2016A030313365)
