摘要
目的探讨卵巢巧克力囊肿合并不孕患者应用腹腔镜手术联合促性腺激素释放激素激动剂(GnRHa)治疗的临床疗效。方法回顾性分析2014年1月至2016年10月期间在茂名化州市中医院妇产科住院治疗的125例卵巢巧克力囊肿合并不孕症患者的临床资料,根据治疗方法的不同,将单纯接受腹腔镜手术治疗的75例患者纳入对照组,腹腔镜手术联合GnRHa治疗的50例患者纳入观察组,比较两组患者术前及术后3个月血清卵泡刺激素(FSH)、雌激素(E2)、黄体生成素(LH)的水平。同时,记录并比较两组患者术后两年内的复发及妊娠情况。结果术后3个月,观察组患者的血清FSH、LH、E2水平分别为(4.67±1.34)mIU/mL、(10.08±2.23)mIU/mL、(48.29±14.31)pmol/L,明显低于对照组的(6.53±1.57)m IU/mL、(13.28±2.75)m IU/mL、(69.64±18.46)pmol/L,差异均有统计学意义(P<0.05);术后随访2年,观察组患者的妊娠率为42.0%,明显高于对照组的24.0%,复发率为6.0%,明显低于对照组的17.3%,差异均有统计学意义(P<0.05)。结论应用腹腔镜手术联合GnRHa治疗卵巢巧克力囊肿合并不孕,可以有效降低患者体内雌激素水平,有效抑制术后的复发,且可以提高患者的妊娠率。
Objective To investigate the clinical efficacy of laparoscopic surgery combined with gonadotropin releasing hormone agonists(GnRHa) in the treatment of ovarian chocolate cysts associated infertility. Methods The clinical data 125 patients with ovarian chocolate cysts associated infertility, who admitted to Department of Obstetrics and Gynecology, Maoming Huazhou Hospital of Traditional Chinese Medicine from January 2014 to October 2016,were retrospectively analyzed. According to the different treatment methods, 75 patients who received laparoscopic surgery alone were included into the control group, and 50 patients who received laparoscopic surgery combined with GnRHa were included into the observation group. The serum follicles of the two groups before and after 3 months were compared. The levels of stimulating hormone(FSH), estrogen(E2), and luteinizing hormone(LH) was detected at the same time, and the recurrence and pregnancy of the two groups within two years after operation were recorded and compared. Results Three months after operation, the levels of serum FSH, LH and E2 in the observation group were(4.67±1.34) mIU/mL,(10.08 ±2.23) mIU/mL,(48.29±14.31) pmol/L, respectively, which were significantly lower than(6.53±1.57) mIU/mL,(13.28±2.75) m IU/mL,(69.64±18.46) pmol/L in the control group(all P<0.05). After 2 years of follow-up, the pregnancy rate(42.0%) in the observation group was significantly higher than that in the control group(24.0%);the recurrence rate(6.0%) in the observation group was significantly lower than that in the control group(17.3%);the differences were ststistically significant(P<0.05). Conclusion In the treatment of ovarian chocolate cysts associated infertility, laparoscopic surgery combined with GnRHa can effectively reduce the level of estrogen in patients,effectively inhibit the recurrence after surgery, and improve the pregnancy rate of patients.
作者
曾治华
李燕
周倩羽
ZENG Zhi-hua;LI Yan;ZHOU Qian-yu(Department of Obstetrics and Gynecology, Maoming Huazhou Hospital of Traditional Chinese Medicine, Maoming 525100, Guangdong, CHINA)
出处
《海南医学》
CAS
2019年第12期1545-1547,共3页
Hainan Medical Journal
