摘要
乙型肝炎病毒(hepatitis B virus,HBV)感染在全球分布,持续HBV复制是导致肝硬化失代偿、肝衰竭及肝癌等终末期肝病发生和发展的主要原因。核苷(酸)类似物[nucleoside(acid)analogues,NAs]具有快速抑制HBV复制的强效作用,作为慢性乙型肝炎(chronic hepatitis B,CHB)抗病毒治疗的主要药物在全球内应用。随着NAs使用的时间延长,国内外关于NAs所致的肾毒性、横纹肌溶解综合征、乳酸酸中毒等不良反应的报道逐渐增多。本文就NAs对CHB患者肾脏安全性进行综述,以期更好地指导抗病毒治疗。
Hepatitis B virus(HBV) infection is distributed globally, and sustained HBV replication is the main cause of end-stage liver disease such as decompensated liver cirrhosis, liver failure and liver cancer. Nucleoside(acid)analogues(NAs) have a potent inhibitory effect on HBV replication and are used globally as the main drugs for antiviral therapy for patients with chronic hepatitis B. With the prolonged use of NAs, reports of adverse reactions such as renal toxicity, rhabdomyolysis syndrome, and lactic acidosis caused by NAs have been increasing at home and abroad.Therefore, this article reviews renal toxicity of NAs in patients with chronic hepatitis B in order to better guide antiviral therapy.
作者
杨燕卿
储君
林世德
YANG Yan-qing;CHU Jun;LIN Shi-de(Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou, CHINA)
出处
《海南医学》
CAS
2019年第12期1587-1591,共5页
Hainan Medical Journal
基金
国家自然科学基金(编号:81460124、81860114)
