摘要
目的评价中药熏蒸联合泪道栓子植入对治疗重度干眼患者视觉相关生存质量的影响。方法采用回顾性病例研究,观察2015年1月—2017年6月就诊于乐山市中医医院眼科门诊确诊的60例(80只眼)重度干眼患者,对照组采用人工泪液联合双氯芬酸钠滴眼液滴眼,实验组予以中药滋阴润目方熏蒸联合下泪点植入SmartPlugTM泪道栓子,双氯芬酸钠滴眼液滴眼,对比评价两组治疗前以及治疗后3个月、6个月的泪膜破裂时间、泪液分泌试验、角膜荧光染色评分、主观症状积分及视觉相关生存质量(VRQOL)评分。结果治疗前泪膜破裂时间:实验组(2.60±0.84)s,对照组(2.40±0.78)s;泪液分泌试验:实验组(2.50±0.68)mm,对照组(2.48±0.85)mm;角膜荧光染色评分:实验组(9.03±1.44),对照组(8.78±1.40);主观症状评分:实验组(8.00±1.04),对照组(7.12±1.02);VRQOL评分:实验组(83.53±4.79),对照组(83.25±4.79),两组各项指标差异无统计学意义(P>0.05)。而在治疗3个月及6个月后,两组间各项指标差异均有统计学意义(P<0.05),且实验组的指标改善较对照组更为明显。结论中药熏蒸联合泪道栓子植入可以明显改善重度干眼患者的临床症状,提高患者视觉相关生存质量。
OBJECTIVE To evaluate the effects of fuming and steaming and lacrimal plug treatment on vision-related quality of life of severe dry eye cases.METHODS It was a retrospective study.Sixty cases(eighty eyes)with severe dry eye were divided into two groups.One group received fuming and steaming treatment in addition to SmartPlugTM lacrimal plugs in inferior punctum and the other group received artificial tears as routine treatment,besides,both groups were also treated with diclofenac sodium eye drops.Schirmer's test,tear film break-up time,corneal fluorescein staining scores,personal symptoms scores,and vision-related quality of life scores before and after different treatment for 3 month and 6 month were documented and compared in pairs.RESULTS Before treatment:Result of Schirmer's test were(2.60±0.84)s in experimental group and(2.40±0.78)s in control group.Result of tear film break-up time were(2.50±0.68)mm in experimental group and(2.48±0.85)mm in control group.Outcome of corneal fluoresce in staining score were 9.03±1.44 in experimental group and 8.78±1.40 in control group.Outcome of subjective symptoms score were 8.00±1.04 in experimental group and 7.12±1.02 in control group.Result of vision-related quality of life were 83.53±4.79 in experimental group and 83.25±4.79 in control group.There were no significant different in Schirmer's test,tear film break-up time,corneal fluorescein staining score,subjective symptoms score and vision-related quality of life score between two groups before the treatment(all P>0.05).While 3 months and 6 months after treatment,all the observed outcome showed significant differences(all P<0.05).Specifically,the experimental group received more obvious improvement than the control group.CONCLUSIONS Fuming and steaming and lacrimal plug treatment obviously alleviated symptoms and improved vision-related quality of life in severe dry eye patients.
作者
刘小虎
邹浩东
李娟
曹斌
刘小玲
丁春梅
蒋敏
LIU Xiaohu;ZOU Haodong;LI Juan(Ineye Ophthalmology Hospital of Chengdu University of TCM,Chengdu 610000,China)
出处
《中国中医眼科杂志》
2019年第3期202-205,共4页
China Journal of Chinese Ophthalmology
关键词
干眼
中药熏蒸
泪道栓子
视觉相关生存质量
泪液分泌试验
dry eye
fuming and steaming treatment
lacrimal plug
vision-related quality of life
Schirmer's test
