摘要
目的:分析甲状腺功能亢进(甲亢)患者尿碘含量及其与甲状腺激素的相关性。方法:分别选取2018年期间武汉大学人民医院体检人群384例(对照组)和甲亢患者164例(甲亢组),采用碘催化砷铈反应检测尿液中尿碘含量,采用化学发光法检测血清中游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)和促甲状腺素(TSH)水平,比较各组尿碘水平及尿碘缺乏率或过量率,并分析甲亢患者尿碘含量与FT3、FT4、TSH水平的相关性。结果:甲亢组尿碘含量为136.38±81.49μg/L,较对照组人群(196.26±109.65μg/L)明显降低(P<0.01);对照组男性尿碘水平(211.84±107.24μg/L)显著高于女性(174.68±109.63μg/L)(P<0.01)。相关分析显示,甲亢患者尿碘与FT3和FT4均呈显著正相关(r=0.435,0.445,P<0.01),与TSH呈显著负相关相关系数为(r=-0.447,P<0.01)。结论:尿碘含量与甲状腺功能密切相关,甲亢患者定期检测尿碘水平,对指导其科学补碘具有重要的临床意义。
Objective: To analyze the relationship betwean urine iodine(UI) and thyroid hormone in hyperthyroidism patients.Method: 384 healthy people and 164 hyperthyroidism patients were selected in this study. UI was detected by ioaine catalyzes arseniccerium reaction. The level of FT3,FT4,TSH were detected by chemiluminescence. The level of UI and the correlation between UI and FT3,FT4,TSH were compared and analyzed. Results: Compared with healthy controls(196.26±109.65μg/L), the level of UI in hyperthyroidism patients(136.38±81.49μg/L) was significantly lower(P<0.001), While in healthy controls, the level of UI in male(211.84±107.24μg/L) was much more higher than female(174.68±109.63μg/L). According to the Spearman’s analysis, UI had a positive relationship with FT3 and FT4(r=0.435,r=0.445, respectively), had a negative relationship with TSH(r=-0.447). Conclusion: The level of UI has a significant relationship with thyroid fuction.Monitoring the level of urine iodine in hyperthyroidism patients, is important to clinics for guiding to guide the iodine supplemnet.
作者
戴雯
宁美薇
李艳
DAI Wen;NING Mei-wei;Li Yan(Department of Clinical Laboratory. Ren min Hospital of Wuhan University,Wuhan 430060,China;Department of Medical Laboratory and Technology,Hubei University of Chinese Medicine, Wuhan 430000, China)
出处
《微循环学杂志》
2019年第2期69-71,77,共4页
Chinese Journal of Microcirculation
