摘要
非洲猪瘟(African swine fever,ASF)是由非洲猪瘟病毒(African swine fever virus,ASFV)引起的一种急性、烈性、出血性的猪传染性疫病,给疫情发生国家(地区)的养猪业带来严重的经济损失。ASFV 作为双股DNA 病毒,含有150-167 个开放阅读框(ORFs),编码200 余种蛋白质,其中结构蛋白约50 种。结构蛋白作为病毒颗粒的主要组分,在病毒吸附、侵入和复制等感染过程中起着重要作用。综述了ASFV 结构蛋白在病毒感染中的作用,以期为ASFV 结构蛋白的进一步研究提供参考。
African swine fever(ASF)is an acute,lethal,and hemorrhagic porcine infectious disease caused by African swine fever virus(ASFV)which has been caused serious economic losses to the pig industry. ASFV is a double-stranded DNA virus. The viral genome contains between 150 and 167 open reading frames(ORFs),and encodes for more 200 proteins,around 50 of them are structural proteins. The structural proteins service as the major composition of viral particles,and play important roles in the assembly of virions,viral adsorption, entry and replication. This paper reviews the roles of ASFV structural proteins in viral infection,and provides guidelines for further studies in the structural proteins of ASFV.
作者
欧云文
刘俐君
代军飞
马炳
张永光
张杰
OU Yun-wen;ZHANG Jie;LIU Li-jun;DAI Jun-fei;MA Bing;ZHANG Yong-guang(State Key Laboratory of Veterinary Etiological Biology,Lanzhou Veterinary Research Institute,Chinese Academy of Agricultural Sciences;Animal Disease Prevention and Control Center of Kaijiang County;Animal Disease Prevention and Control Center of Dazhou)
出处
《生物技术通报》
CAS
CSCD
北大核心
2019年第6期156-163,共8页
Biotechnology Bulletin
基金
“十三·五”国家重点研发计划子课题(2017YFD0501801)
四川省科技计划项目(19MZGC0107)
关键词
非洲猪瘟病毒
结构蛋白
致病机理
感染
African swine fever virus
structural proteins
pathogenic mechanism
infection
