摘要
目的探讨老年慢性阻塞性肺疾病(COPD)患者呼出气一氧化氮(FeNO)、呼出气一氧化碳(FeCO)水平及意义。方法选取2016年1月至2017年12月在无锡市人民医院呼吸科门诊治疗的老年COPD患者40例为COPD组,其中吸烟患者20例,不吸烟患者20例,同时选取健康志愿者40例作为对照组,其中吸烟者20例,不吸烟者20例,检测受试者FeNO、FeCO、第1秒用力呼气容积占预计值百分比(FEV1%pred)和第1秒用力呼气容积与用力肺活量比值(FEV1/FVC)水平。结果COPD组FeNO和FeCO分别为(20.44±8.34)ppb和(8.43±2.01)ppb,明显高于对照组(t=7.354、5.960,P值均<0.05),而FEV1%pred和FEV1/FVC分别为(42.28±6.82)%和(53.39±9.22)%,明显低于对照组(t=38.020、20.409,P值均<0.05);COPD组吸烟者FeNO为(17.66±4.22)ppb、明显低于COPD组未吸烟者(t=-7.832,P<0.05),但明显高于对照组吸烟和未吸烟者(t=4.822、6.012,P值均<0.05);COPD组吸烟者FeCO为(9.44±1.62)ppb,明显高于COPD组未吸烟者、对照组吸烟和未吸烟者(t=8.418、9.281、10.033,P值均<0.05);COPD组FeNO、FeCO与FEV1%pred、FEV1/FVC无相关性(r=0.132、0.122、0.118、0.105,P值均>0.05);对照组FeNO与FEV1%pred呈正相关(r=0.433,P<0.05)。结论老年COPD患者FeNO和FeCO明显升高,而吸烟可导致FeNO降低,而FeNO、FeCO与COPD患者肺功能无明显关系。
Objective To investigate the level and significance of exhaled nitric oxide (FeNO) and exhaled carbon monoxide (FeCO) in elderly patients with chronic obstructive pulmonary disease (COPD). Methods From January 2016 to December 2017, 40 elderly patients with COPD (COPD group) were selected in Wuxi People′s Hospital, including 20 smokers and 20 non-smokers, 40 healthy volunteers were selected as the control group, including 20 smokers and 20 non-smokers, the FeNO, FeCO, ratio of forced expiratory volume in the forced expiratory volume in one second as a percentage of expected value(FEV1%pred)and ratio of FEV1 to forced vital capacity (FEV1/FVC) were measured. Results FeNO and FeCO in COPD group were (20.44±8.34) ppb and (8.43±2.01) ppb, which were significantly higher than those in control group (t=7.354, 5.960, both P<0.05), while FEV1%pred and FEV1/FVC were (42.28±6.82)% and (53.39±9.22)%, which were significantly lower than those in control group (t=38.020, 20.409, both P<0.05). The FeNO of smokers in COPD group was (17.66±4.22) ppb, significantly lower than that of non-smokers in COPD group (t=-7.832, P<0.05), but significantly higher than that of smokers and non-smokers in normal group (t=4.822, 6.012, both P<0.05). The FeCO of smokers in COPD group was (9.44±1.62) ppb, which were significantly higher than that of non-smokers, normal smokers and non-smokers in COPD group (t=8.418, 9.281, 10.033, all P<0.05). FeNO and FeCO were not correlated with FEV1% pred and FEV1/FVC in COPD group (r=0.132, 0.122, 0.118, 0.105, all P>0.05). FeNO was positively correlated with FEV1%pred in normal group (r=0.433, P<0.05). Conclusions FeNO and FeCO are increase significantly in elderly patients with COPD, while smoking can decrease FeNO, FeNO and FeCO has no significant relationship with lung function in COPD patients.
作者
吕剑
吴艳
卞涛
范晓东
Lv Jian;Wu Yan;Bian Tao;Fan Xiaodong(Department of Respiratory and Critical Care Medicine,Wuxi People′s Hospital,Wuxi 214000,China)
出处
《国际呼吸杂志》
2019年第11期825-829,共5页
International Journal of Respiration
基金
江苏省干部保健科研2015年中标课题(BJ15009).
关键词
肺疾病
慢性阻塞性
老年人
呼出气一氧化氮
呼出气一氧化碳
Pulmonary disease, chronic obstructive
Aged
Exhaled nitric oxide
Expiratory carbon monoxide
