摘要
新型抗肿瘤药物显著提高了肿瘤患者的存活时间,与此同时,抗肿瘤药物导致的肾损伤及其对肿瘤患者预后造成的不良影响越来越受到关注。传统化疗药物主要通过对肾小管的直接毒性造成肾损伤,而新型抗肿瘤药物造成的肾损伤类型多,包括急性肾小管损伤、血栓性微血管病、间质性肾炎、肾小球疾病等,由于发病机制不同,需要明确诊断.给予不同的治疗。文章重点介绍抗肿瘤药物,尤其对新型抗肿瘤药物导致肾损伤的危险因素、损伤类型、发病机制及防治进行综述。
Novel antineoplastic drugs have significantly prolonged the survival time of cancer patients. Meanwhile,nephrotoxicity of antineoplastic drugs and its adverse effects on the prognosis of cancer patients have received increasing attention. Conventional chemotherapy causes kidney injury mainly through direct renal toxicity,while new anti-tumor drugs can induce a number of kidney damage,including acute renal tubular injury,thrombotic microangiopathy,interstitial nephritis,and glomerular diseases through multiple mechanisms. Clinicians must be knowledgeable in the renal toxicity of antineoplastic drugs to minimize the nephrotoxicity of the drugs and diagnose early,especially in patients with underlying kidney disease. This article focuses on the risk factors,clinical and histological patterns,pathogenesis,prevention and treatment of renal injury associated with the antineoplastic drugs,especially novel targeted antineoplastic drugs.
作者
石朋先
任贵生
胡伟新
SHI Peng-xian;REN Gui-sheng;HU Wei-xin(National Clinical Research Center of Kidney Diseases,Jinling Hospital,Nanjing Medical University,General Hospital of Eastern Theater Command,PLA,Nanjing 210002,Jiangsu,China)
出处
《医学研究生学报》
CAS
北大核心
2019年第6期652-656,共5页
Journal of Medical Postgraduates
基金
国家自然科学基金(81770701)
关键词
抗肿瘤药物
药物肾毒性
急性肾损伤
antineoplastic drug
drug nephrotoxicity
acute kidney injury
