摘要
目的探讨脑梗死急性期患者的脑微出血(cerebral microbleeds,CMBs)的危险因素。方法连续搜集2014年1月至2016年12月于福建医科大学附属第一医院神经内科住院的脑梗死急性期患者255例。根据脑微出血的部位和数目进行分组:幕下CMBs无或轻度组/中重度组、皮质CMBs无或轻度组/中重度组、深部CMBs无或轻度组/中重度组,比较不同部位各亚组之间估算的肾小球滤过率(estimated glomerular filtration rate,eGFR)水平及常见动脉硬化危险因素等的差异,并行多因素回归分析。结果共有140例患者(54.9%)存在CMBs。在幕下组中,中重度CMBs患者伴低eGFR水平的比例较无/轻度CMBs患者高(P=0.024)。低eGFR水平(OR=3.874,95%CI:1.261~11.901,P=0.018)、高血压病程(OR=2.128,95%CI:1.004~4.510,P=0.049)是幕下中重度CMBs的独立危险因素。结论肾功能不全、长高血压病程是脑梗死患者发生幕下中重度微出血的危险因素。
Objective To analyze the risk factors of cerebral microbleeds (CMBs) in acute cerebral infarction patients. Methods We consecutively included 255 acute cerebral infarction patients who were admitted in Neurology Department of the First Affiliated Hospital of Fujian Medical University from January 2014 to December 2016. According to the number and location of CMBs, the patients were divided into infratentorial, cortical and deep cerebral groups, each of which included non-mild and moderate-severe subgroups. The differences of the level of glomerular filtration rate (eGFR) and some common arteriosclerotic risk factors were analyzed between subgroups, and the multiple logistic regression analysis was performed. Results A total of 140 subjects (54.9%) had CMBs. In the infratentorial group, the proportion of patients who were with low eGFR level in the moderate-severe CMBs subgroup was higher than in the non-mild CMBs subgroup (P=0.024). The low eGFR level (OR=3.874, 95% CI:1.261~11.901, P=0.018) and the long duration of hypertension (OR=2.128, 95%CI: 1.004~4.510, P=0.018) were the independent risk factors of the moderate-severe infratentorial CMBs. Conclusion The low eGFR level and long duration of hypertension are risk factors for the moderate and severe infratentorial CMBs after acute ischemic stroke.
作者
蔡乃青
谢丽桔
李智文
张清香
张胜
王丹妮
刘小艳
段心怡
林红
蔡斌
CAI Naiqing;XIE Liju;LI Zhiwen;ZHANG Qingxiang;ZHANG Sheng;WANG Dan’ni;LIU Xiaoyan;DUAN Xinyi;LIN Hong;CAI Bin(Department of Neurology,the First Affiliated Hospital of Fujian Medical University,Fuzhou 350003,China)
出处
《中国神经精神疾病杂志》
CAS
CSCD
北大核心
2019年第6期326-330,共5页
Chinese Journal of Nervous and Mental Diseases
基金
国家自然科学基金[编号:81171114(BC),81571133(BC)]
福建省中青年医学人才项目[编号:2014-ZQN-ZD-18(BC),2015-ZQN-JC-21(LF)]
福建省自然科学基金[编号:2015J01392(BC)]
福建省重大专题专项(编号:2017YZ0001-1)
福建省重点临床专科项目
关键词
脑微出血
脑梗死急性期
EGFR
危险因素
Cerebral microbleeds
Acute ischemic stroke
Risk factor
eGFR level
