摘要
目的研究血清胎盘生长因子(PlGF)在慢性心力衰竭患者中的应用效果,为临床相关诊治提供参考。方法选取2015年1~3月云南省第三人民医院(以下简称“我院”)收治的慢性心力衰竭患者85例作为观察组,同期选取我院参加健康体检的60名健康者作为对照组。采用酶联免疫吸附法(ELISA法)检测两组患者PlGF、高敏C-反应蛋白(hs-CRP)及肿瘤坏死因子-α(TNF-α)含量,各心功能分级血清指标含量,并对观察组患者进行对症治疗,其后再比较各血清指标变化。结果观察组治疗前血清PlGF、hs-CRP及TNF-α含量均高于对照组,差异均有统计学意义(P < 0.05);随着患者心功能分级增高,其血清PlGF、hs-CRP及TNF-α含量均升高,差异均有统计学意义(P < 0.05);观察组治疗后血清PlGF、hs-CRP及TNF-α含量低于治疗前,差异均有统计学意义(P < 0.05)。结论慢性心力衰竭患者血清PlGF、hs-CRP及TNF-α含量均较健康者升高,且随着心功能分级增高而上升,经对症治疗,可有效改善患者上述指标,为临床诊治提供重要参考。
Objective To study the effect of serum placental growth factor (PlGF) in patients with chronic heart failure, and to provide reference for clinical diagnosis and treatment. Methods Eighty-five patients with chronic heart failure admitted to the Third People′s Hospital of Yunnan Province (“our hospital” for short) from January to March 2015 were selected as the observation group, and 60 healthy patients who participated in the physical examination in our hospital were selected as the control group. Enzyme-linked immunosorbent assay (ELISA) was used to detect the levels of PlGF, hs-CRP and TNF-α in the two groups. The serum indexes of each cardiac function grade were measured. The patients in the observation group were treated symptomatically, and then the changes of serum indexes were compared. Results The serum levels of PlGF, hs-CRP and TNF-α in the observation group were higher than those in the control group before treatment, and the differences were statistically significant (P < 0.05). The serum levels of PlGF, hs-CRP and TNF-α in the observation group increased with the increase of cardiac function grade, and the differences were statistically significant (P < 0.05). The serum levels of PlGF, hs-CRP and TNF-α in the observation group after treatment were lower than those before treatment, and the differences were statistically significant (P < 0.05). Conclusion The serum levels of PlGF, hs-CRP and TNF-α in patients with chronic heart failure are higher than those in healthy people, and increase with the increase of cardiac function grade. Symptomatic treatment can effectively improve the above-mentioned indicators of patients and provide important reference for clinical diagnosis and treatment.
作者
魏引
何亚磊
蔡叶锐
周季
张鑫
常业飞
WEI Yin;HE Yalei;CAI Yerui;ZHOU Ji;ZHANG Xin;CHANG Yefei(Department of Cardiology, the Third People′s Hospital of Yunnan Province, Yunnan Province, Kunming 650000, China)
出处
《中国医药导报》
CAS
2019年第17期39-41,71,共4页
China Medical Herald
基金
云南省教育厅科学研究基金项目(2016ZDX112)
