摘要
目的:探讨糖通饮对早期糖尿病肾病大鼠肾脏组织的保护作用。方法:雄性SD大鼠55只,随机分为正常组(A组)10只,剩余的45只造模,将造模成功的40只SD大鼠分为模型组(B组)、糖通饮组(C组)、厄贝沙坦组(D组)及糖通饮+厄贝沙坦组(E组),每组10只;C、D、E组给予对应的药物灌胃治疗,A组及B组给予等量生理盐水灌胃,8周末检测大鼠的空腹血糖(FBG)、血清肌酐(SCr)及24h尿蛋白定量,取右侧肾脏苏木精-伊红(HE)染色光镜下观察组织学改变。结果:与A组比较,B组大鼠肾脏病理形态变化明显,FBG、SCr及24h尿蛋白明显升高,差异有统计学意义(P<0.05);与B组比较,C、E组的FBG、SCr及24h尿蛋白明显降低,D组的SCr及24h尿蛋白明显降低,差异有统计学意义(P<0.05);与B组比较,C、D、E组治疗后病理改变均明显减轻。结论:糖通饮能够有效地减少早期DN大鼠的24h尿蛋白,降低FBG和SCr水平,对大鼠肾脏组织具有保护作用。
Objective: To investigate the protective effects of Tangtong Drink on kidney tissue of rats with early diabetic nephropathy. Methods: A total of 55 male Sprague-Dawley rats were randomly divided into normal (A) group ( n =10),and the remaining 45 rats were modeled.40 SD rats with successful modeling were divided evenly into model (B) group,Tangtong Drink (C) Group,Irbesartan (D) group,and Tangtong Drink+Irbesartan (E) group.Group C,D,and E were given the corresponding drugs for intragastric administration,and group A and group B were given the same amount of normal saline.After 8 weeks,the fasting blood glucose (FBG),serum creatinine (SCr) and 24 h urine protein were measured.The pathological changes of rat kidney were observed under hematoxylin-eosin (HE) staining. Results: Compared with group A,the pathological changes of kidney in group B were significantly changed.FBG and SCr and 24 h urine protein significantly increased ,and the differences were statistically significant ( P <0.05).Compared with group B,FBG,SCr and 24 h urinary protein in group C and E significantly decreased,and SCr and 24 h urine protein significantly lower in group D.The differences were statistically significant ( P <0.05).Compared with group B,the pathological changes were all significantly reduced in group C,D,and E. Conclusion: Tangtong Drink could effectively reduce the levels of FBG and SCr in rats with diabetic nephropathy and reduce 24 h urine protein,which showed protective effects of kidney tissues in rats.
作者
高楠楠
侯胜开
屈璐
潘艳伶
GAO Nannan;HOU Shengkai;QU Lu;PAN Yanling(Department of Traditional Chinese Medicine,School of Clinical Medicine,Guizhou Medical University,Guiyang 550004,Guizhou,China;Guizhou Provincial Key Laboratory of Pathogenesis & Grug Research on Common ChronicDiseases,Guizhou Medical University,Guiyang 550025,Guizhou,China)
出处
《贵州医科大学学报》
CAS
2019年第6期675-679,共5页
Journal of Guizhou Medical University
基金
贵阳市人民政府-贵州医科大学科学技术联合基金(GY2015-21)
关键词
糖尿病肾病
糖通饮
厄贝沙坦
尿蛋白
血清肌酐
病理学
diabetic nephropathy
Tangtong drink
irbesartan
urine protein
serum creatinine
pathology
