摘要
目的增加对病理组织类型为伴有骨及软骨分化的乳腺梭形细胞化生性癌的了解,并增加相关诊治经验。方法讨论1例伴有骨及软骨分化的乳腺梭形细胞化生性癌,自术前检查至术后16个月诊治经过,结合其余文献所涉及的相似病理组织学情况进行研究。结果该例患者经术后病理多次取材、染色以及与外院专家会诊,最终确诊为伴有骨及软骨分化的乳腺梭形细胞化生性癌,术后随访16个月,未见局部复发及远处转移。结论伴有骨及软骨分化的梭形细胞化生性癌是一种罕见的乳腺化生性癌,其临床表现与非特殊类型浸润性乳腺癌相似,在影像学上亦无特异表现。术前诊断困难,容易漏诊及误诊。需要术后多次取材及多块组织进行上皮标记物免疫组化染色,才能确诊,其预后的判断和临床治疗方案参照普通乳腺化生性癌制定。
Objective The aim of the present study was to increase the understanding of spindle cell metaplastic carcinoma of breast with bone and cartilage differentiation and the experience of diagnosis and treatment of the disease. Methods The diagnosis and treatment of a special case which is spindle cell metaplastic carcinoma of breast with bone and cartilage differentiation from preoperative examination to 16 months after operation was discussed. This case was studied in conjunction with similar histopathological findings in other literature. Results The patient was diagnosed as spindle cell metaplastic carcinoma of the breast with bone and cartilage differentiation after repeated pathological sampling,staining and consultation with experts from other hospitals. And she was followed up for 16 months without local recurrence or distant metastasis. Conclusion Spindle cell metaplastic carcinoma with bone and cartilage differentiation is a rare kind of breast metaplastic carcinoma. Its clinical manifestation is similar to that of non-specific invasive breast cancer,and there is no specific imaging manifestation. Preoperative diagnosis of this disease is difficult and easily to miss and misdiagnose. So it is necessary to take samples and many tissues for immunohistochemical staining of epithelial markers for definite diagnosis after the operation. The prognosis and clinical treatment of this disease can be referred to general breast metaplastic carcinoma.
作者
苑著
屈翔
张忠涛
于乐漪
张淑红
YUAN Zhu;QU Xiang;ZHANG Zhong-tao(Department of General Surgery,Beijing Friendship Hospital,Capital Medical University,Beijing Key Laboratory of Cancer Invasion and Metastasis Research & National Clinical Research Center for Digestive Diseases,Beijing 100050,China;Department of Pathology,Beijing Friendship Hospital,Capital Medical University,Beijing 100050)
出处
《临床和实验医学杂志》
2019年第13期1427-1429,共3页
Journal of Clinical and Experimental Medicine
基金
北京市卫生系统“215”高层次人才培养计划(编号:2015-3-008)
关键词
乳腺
梭形细胞
化生性癌
骨
软骨
Breast
Spindle cell
Metaplastic carcinoma
Osseous
Cartilaginous
