摘要
目的系统评价大株红景天注射液联合常规疗法治疗心力衰竭的临床疗效。方法计算机检索中英文数据库,收集大株红景天注射液治疗心力衰竭的临床随机对照试验(RCT)文献,检索时间为建库至2018年12月。按照Cochrane系统评价手册对纳入文献进行质量评价,运用RevMan 5.3和Stata12.0软件,对大株红景天注射液治疗心力衰竭的临床疗效进行Meta分析。结果共纳入15篇RCT文献,涉及患者1 549例。Meta分析结果显示,与常规疗法相比,大株红景天注射液联合常规疗法治疗心力衰竭有更好的综合疗效[OR=3.59,95%CI(2.45,5.26),P<0.000 01],并能提高左心室射血分数[SMD=1.10,95%CI(0.98,1.23),P<0.000 01],改善左心室舒张末期内径[SMD=-0.9,95%CI(-1.32,-0.48),P<0.000 01],降低血浆脑钠肽[SMD=-1.43,95%CI(-2.19,-0.68),P<0.000 01]和N末端B型脑钠肽前体[SMD=-4.89,95%CI(-7.50,-2.29),P<0.000 01]水平,提高6 min步行距离[MD=29.26,95%CI(20.90,37.61),P<0.000 01]。结论大株红景天注射液联合常规疗法治疗心力衰竭疗效优于单纯使用常规治疗;纳入分析的文献质量和数量有限,结论有待后续研究验证。
Objective To systematically evaluate the clinical efficacy of Sofren Injection combined with conventional therapy in treatment of heart failure. Method A computer-based search of Chinese and English databases was conducted on December 2018 to collect literatures on clinical randomized controlled trials ( RCTs) with Sofren Injection in the treatment of heart failure. Quality evaluation was performed on the literatures included according to Cochrane Handbook for Systematic Reviews of Interventions. Using RevMan 5.3 and Stata 12.0,the clinical efficacy of Sofren Injection in the treatment of heart failure was analyzed by meta-analysis. Results Totally 15 RCTs with 1,549 patients were included. The results of meta-analysis showed that compared with conventional therapy,Sofren Injection combined with conventional therapy had better comprehensive efficacy in treating heart failure [OR= 3.59,95% CI ( 2.45,5.26),P< 0.000 01],increased the left ventricular ejection fraction ( LVEF)[SMD = 1.10,95% CI ( 0.98, 1.23),P<0.000 01],improved the left ventricular end-diastolic diameter[SMD=-0.9,95% CI (-1.32,-0.48),P<0.000 01],reduced the levels of plasma brain natriuretic peptide ( BNP)( SMD=-1.43,95% CI (-2.19,-0.68),P<0.000 01) and N-terminal B-type BNP precursor ( SMD =-4.89,95% CI (-7.50,-2.29),P<0.000 01),and increased the walking distance in 6-minute walking test [MD = 29.26,95% CI ( 20.90,37. 61),P<0.000 01]. Conclusion The efficacy of Sofren Injection combined with conventional therapy is superior to that of conventional therapy alone in treatment of heart failure. However,the quality and quantity of the literatures included in the analysis are limited,and the conclusion needs to be verified with follow-up studies.
作者
欧阳炜
董玉娟
朱雅玲
OUYANG Wei;DONG Yujuan;ZHU Yaling(Department of Pharmacy,Guangdong Second Traditional Chinese Medicine Hospital,Guangzhou 510095,China)
出处
《上海中医药杂志》
2019年第7期37-43,共7页
Shanghai Journal of Traditional Chinese Medicine
基金
广东省医院药学研究基金(正大天晴基金)项目(2017A03)
