摘要
目的探讨血清高迁移率族蛋白B1(HMGB1)水平与T2DM下肢动脉硬化闭塞症(LASO)患者支架植入术后再狭窄的相关性。方法选取2015年1月至2017年1月于唐山工人医院就诊的T2DM合并LASO患者92例作为研究对象,均成功接受血管介入(球囊扩张+支架植入)治疗,根据是否出现再狭窄分为再狭窄组(RS组,n=34)和未狭窄组(NS组,n=58)。收集术前基线资料,包括年龄、性别、病程、吸烟史、BMI、SBP、DBP、踝肱指数(ABI)、FPG、HbA1c、TC、TG、HDL-C、LDL-C及超敏C反应蛋白(hsC-RP)。ELISA检测术前血清HMGB1水平。结果(1)与NS组比较,RS组术前HMGB1水平较高[(18. 32±4. 57)vs(12. 29±3. 16),P<0. 01];(2)HMGB1与HbA1c、LDL-C、hsC-RP呈正相关(P<0. 05);(3)HMGB1水平是T2DM合并LASO患者支架植入术后再狭窄的独立危险因素(OR=1. 915,P=0. 003);(4)与低HMGB1组相比,高HMGB1组支架植入术后再狭窄的发生率明显增加(P<0. 05);(5)ROC分析提示,术前HMGB1水平在T2DM合并LASO患者支架植入术后再狭窄中的最佳界值为15. 15 ng/ml,特异性84. 13%,敏感性75. 86%。结论 T2DM合并LASO患者术前高血清HMGB1水平,可能参与了其支架植入术后再狭窄的发生及发展。
Objective To investigate the correlation between preoperative serum high mobility group box 1 protein(HMGB1)and postoperative in-sent restenosis in type 2 diabetic patients with lower limb arteriosclerosis obliterans(LASO).Methods92 T2 DM patients with LASO who underwent interventional therapy(balloon dilatation and stent implantation)in Tangshan Gongren hospital from Jan 2015 to Jan 2017 were recruited. They were divided into restenosis group(RS,n=34)and non-stenosis group(NS,n=58)based on whether or not in-stent restenosis occurred. Baseline information including age,sex,course of disease,smoking history,body mass index(BMI),systolic blood pressure(SBP),diastolic blood pressure(DBP),ankle brachial index(ABI),fasting plasma glucose(FPG),glycosylated hemoglobin A1 c(HbA1 c),total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),highdensity lipoprotein cholesterol(HDL-C)and hypersensitive C-reactive protein(hsC-RP)were collected. Serum HMGB1 was measured by enzyme-linked immunosorbent assay(ELISA).Results(1)Compared with NS group,HMGB1 levels in RS group were higher[(18. 32±4. 57)vs(12. 29±3. 16),P<0. 01];(2)HMGB1 was positively correlated with HbA1 c,LDL-C and hsC-RP(all P<0. 05);(3)HMGB1 was independent risk factor for in-sent restenosis in T2 DM patients with LASO(OR=1. 915,P=0. 003);(4)Compared with the low HMGB1 group,the rate of in-sent restenosis in the high HMGB1 group was significantly increased;(5)ROC analysis indicated that the optimal cut-off value of HMGB1 level for restenosis in T2 DM patients combined with LASO was 15. 15 ng/ml,with specificity 84. 13% and sensitivity 75. 86%.ConclusionElevated preoperative serum HMGB1 may be involved in the development and progression of in-sent restenosis in T2 DM patients with LASO.
作者
安彩霞
房辉
杨岳
孙雪玲
刘庆贤
尹贺侠
AN Caixia;FANG Hui;YANG Yue(Department of Endocrinology,Tangshan Gongren Hospital,Tangshan 063000,China)
出处
《中国糖尿病杂志》
CAS
CSCD
北大核心
2019年第6期429-433,共5页
Chinese Journal of Diabetes
关键词
高迁移率族蛋白B1
糖尿病
2型
下肢动脉硬化闭塞症
支架植入
再狭窄
High mobility group box 1 protein
Diabetes mellitus,type 2
Lower limb arteriosclerosis obliterans
In-sent
Restenosis
