摘要
目的了解阳江市人民医院 2016-2018年沙门菌感染情况,分析沙门菌菌株的血清型分布和耐药性,为临床合理用药提供科学依据。方法对阳江市人民医院2016-2018年腹泻的住院患者和门诊患者送检的6 837份大便标本进行分离、鉴定、血清分型和药敏试验,并统计相关流行病学资料。结果 2016-2018年共分离出766株沙门菌,分离率为11.20%;男女沙门菌分离率分别为11.21%、11.19%,差异无统计学意义(P>0.05);婴儿感染率最高(57.83%),幼儿(1~3岁)占25.84%,其他年龄段(≥3岁)占16.32%,各年龄段比较差异有统计学意义(P<0.05);6~10月份为沙门菌患者发病高峰期;766株沙门菌共44种血清型,以Ⅰ4,5,12:i:-为主,占42.82%;Ⅰ4,5,12:i:-、鼠伤寒沙门菌、肠炎沙门菌、斯坦利沙门菌 4种血清型比较差异有统计学意义(P<0.05);氨苄西林、复方新诺明、氯霉素、米诺环素、头孢吡肟、头孢曲松、头孢他啶等7种抗生素耐药率比较差异有统计学意义(P<0.05)。结论在阳江引起感染性腹泻的沙门菌血清型为 I4,5,12:i:-;3年间部分抗生素耐药性变化有统计学差异。临床医生应根据沙门菌药敏结果和患者的具体情况合理规范使用抗生素,避免多重耐药菌株的产生。
Objective To explore the infection of Salmonella infections in Yangjiang People's Hospital from2016 to 2018, and analyze the serotype distribution and drug resistance situation of Salmonella strains, and provide thebasis for clinical rational use of antibiotics. Methods A total of 6 837 stool specimens from diarrhea inpatient and out-patient in Yangjiang People's Hospital from 2016 to 2018 were isolated, identified, serotyped and tested for susceptibilitytested, and related epidemiological data were analyzed. Results A total of 766 Salmonella strains were separated from2016 to 2018, with the overall separation rate of 11.20%, and there was no statistically significant difference in the sepa-ration rate between male (11.21%) and female (11.19%) patients (P>0.05). The infection rate was the highest in infants(57.83%), and the young children (1 to 3 years old), and the other age groups (≥3 years old) accounted for 25.84%,16.32%. There were significant differences among different age groups (all P<0.05). The peak period of Salmonella in-fection was from June to October. The 766 Salmonella strains were classified into 44 serogroups, mainly Ⅰ4, 5, 12:i:-(accounting for 42.82%). There were significant differences among four serotypes ofⅠ4,5,12:i:-, Salmonella typhimuri-um, Salmonella enteritidis and Salmonella Stanley (all P<0.05). There were significant differences in drug resistance ratesof ampicillin, compound neotamine, chloramphenicol, minocycline, cefepime, ceftriaxone and ceftazidime (all P<0.05).Conclusion The main serotype of Salmonella causing infectious diarrhea in Yangjiang isⅠ4, 5, 12:i:-. There are statis-tically significant differences in the changes of antibiotics resistance over 3 years. The clinicians should rationally regu-late the use of antibiotics based on the results of Salmonella susceptibility and the specific conditions of patients, so as toavoid the emergence of multi-drug resistant strains.
作者
黎莉
陈金玲
陈志晓
林飞燕
关志澳
黎青梅
LI Li;CHEN Jing-ling;CHEN Zhi-xiao;LIN Fei-yan;GUAN Zhi-ao;LI Qing-mei(Department of Clinical Laboratory, Yangjiang People's Hospital, Yangjiang 529500, Guangdong, CHINA)
出处
《海南医学》
CAS
2019年第13期1697-1700,共4页
Hainan Medical Journal
关键词
阳江
沙门菌
血清型
耐药
抗生素
Yangjiang
Salmonella
Serotype
Drug resistance
Antimicrobial agent
