摘要
背景 2型糖尿病(T2DM)并冠心病患者因早期无明显临床表现而常漏诊,因此寻找直观、简便且稳定性较好的临床指标对早期预测T2DM患者冠心病发生风险具有重要意义。目的 分析中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)及同型半胱氨酸(Hcy)与T2DM患者冠心病的关系。方法 选取2018年1—10月盘锦辽油宝石花医院收治的T2DM并冠心病患者73例作为观察组,另选取同期收治的单纯T2DM患者86例作为对照组。比较两组患者一般资料及实验室检查指标,T2DM患者冠心病的影响因素分析采用多因素Logistic回归分析。结果 (1)观察组患者年龄大于对照组,收缩压高于对照组,糖尿病病程长于对照组(P<0.05);两组患者性别、体质指数(BMI)、腰臀比、舒张压、高血压病史及高脂血症病史比较,差异无统计学意义(P>0.05)。(2)观察组患者NLR、PLR及Hcy高于对照组(P<0.05);两组患者空腹血糖(FBG)、三酰甘油(TG)及总胆固醇(TC)比较,差异无统计学意义(P>0.05)。(3)多因素Logistic回归分析结果显示,年龄〔OR=3.108,95%CI(2.015,4.793)〕、收缩压〔OR=1.970,95%CI(1.579,2.458)〕、糖尿病病程〔OR=3.827,95%CI(2.326,6.296)〕、NLR〔OR=3.466,95%CI(2.204,5.451)〕、PLR〔OR=3.340,95%CI(2.724,4.095)〕及Hcy〔OR=7.164,95%CI(2.372,21.638)〕是T2DM患者冠心病的独立影响因素(P<0.05)。结论 NLR、PLR及Hcy是T2DM患者冠心病的独立影响因素,定期监测NLR、PLR及Hcy水平有利于预防及早期发现T2DM患者冠心病。
Background Due to lack of noticeable clinical manifestations,type 2 diabetes mellitus(T2DM) patients complicated with coronary heart disease(CHD)often been missed diagnosis,so it is very important to identify intuitive and simple clinical indictors with good stability to early predict the risk of CHD in patients T2DM. Objective To explore the relations of neutrophil to lymphocyte ratio(NLR),platelet to lymphocyte ratio(PLR)and Hcy to CHD in patients with T2DM. Methods From January to October 2018,a total of 73 T2DM patients complicated with CHD were selected as observation group in Panjin Liaohe Oilfield Baoshihua Hospital,meanwhile a total of 86 patients with T2DM only were selected as control group. General information and laboratory examination results were compared between the two groups,and multivariate Logistic regression analysis was used to analyze the influencing factors CHD in patients with T2DM. Results (1)Compared with control group,observation group showed statistically significantly elder age,greater SBP and longer course of diabetes (P<0.05),but similar gender,BMI,waist-hip ratio,DBP,proportion of patients with medical history of hypertension and hyperlipidaemia(P>0.05).(2)NLR,PLR and Hcy in observation group were all statistically significantly higher than those in control group(P<0.05),while no statistically significant difference of FBG,TG or TC was found between the two groups (P>0.05).(3)Multivariate Logistic regression analysis results showed that,age〔OR=3.108,95%CI(2.015,4.793)〕, SBP〔OR=1.970,95%CI(1.579,2.458)〕,course of diabetes〔OR=3.827,95%CI(2.326,6.296)〕, NLR〔OR=3.466,95%CI(2.204,5.451)〕,PLR〔OR=3.340,95%CI(2.724,4.095)〕and Hcy〔OR=7.164,95%CI(2.372,21.638)〕were independent influencing factors of CHD in patients with T2DM(P<0.05). Conclusion NLR,PLR and Hcy are independent influencing factors of CHD in patients with T2DM,thus regularly monitoring the above three may be beneficial to the prevention and early diagnosis of CHD in T2DM patients .
作者
张新
王玲
王世蓉
刘雪松
ZHANG Xin;WANG Ling;WANG Shirong;LIU Xuesong(Panjin Liaohe Oilfield Baoshihua Hospital,Panjin 124010,China)
出处
《实用心脑肺血管病杂志》
2019年第6期44-47,共4页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
