摘要
目的探讨双歧杆菌乳杆菌三联活菌片与蒙脱石散联合治疗小儿腹泻的临床效果。方法选择我院2016年4月至2017年4月收治的94例腹泻患儿为研究对象,按照随机法将其分为研究组和对照组,每组47例。给予两组患儿对症支持与蒙脱石散治疗,研究组增加双歧杆菌乳杆菌三联活菌片。比较两组的临床疗效、临床症状缓解所用时间、治疗前、后5-HT、VIP、NPY指标水平及不良反应发生情况。结果研究组的治疗总有效率显著高于对照组,差异有统计学意义(P<0.05);研究组大便性状变稠、腹痛停止、腹泻停止、大便镜检正常、大便细菌培养正常及正常排便所用时间均显著短于对照组,差异有统计学意义(P<0.05);治疗前,两组5-HT、VIP、NPY水平比较,差异无统计学意义(P>0.05);治疗后,两组5-HT、VIP水平均显著降低,NPY水平均显著升高,差异有统计学意义(P<0.05);治疗后,研究组5-HT、VIP水平均低于对照组,NPY水平高于对照组,差异有统计学意义(P<0.05);两组均未见皮疹、恶心等不良反应。结论双歧杆菌乳杆菌三联活菌片联合蒙脱石散能够有效改善小儿腹泻症状,疗效较为显著,且用药较为安全。
Objective To explore the clinical effect of live combined bifidobacterium and lactobacillus tablets combined with montmorillonite powder in the treatment of infantile diarrhea.Methods A total of 94 children with diarrhea admitted in our hospital from April 2016 to April 2017 were selected as the research objects,and the children were divided into study group and control group according to the random method,with 47 cases in each group.Two groups were given symptomatic support and montmorillonite powder treatment,and the study group added live combined bifidobacterium and lactobacillus tablets.The clinical effects,the time of relieving clinical symptoms,the levels of 5-HT,VIP and NPY before and after treatment and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate of treatment of the study group was significantly higher than that of the control group,and the difference was statistically significant(P<0.05).The time spent in the study group were significantly shorter than those in the control group,including the thickening of stool shape,cessation of abdominal pain,cessation of diarrhea,normal stool microscopy,normal culture of stool bacteria and normal defecation,and the differences were statistically significant(P<0.05).There were no significant differences in the levels of 5-HT,VIP and NPY between the two groups before treatment(P>0.05).After treatment,the levels of 5-HT and VIP in both groups decreased significantly,NPY levels increased significantly,and the differences were statistically significant(P<0.05).After treatment,the levels of 5-HT and VIP in the study group were lower than those in the control group,and NPY level was higher than that in the control group,and the differences were statistically significant(P<0.05).There were no adverse reactions such as rash and nausea in both groups.Conclusion Live combined bifidobacterium and lactobacillus tablets combined with montmorillonite powder can effectively improve the symptom of diarrhea in children,with remarkable curative effect and high safety.
作者
赵宏艳
ZHAO Hong-yan(Traditional Chinese Medicine Hospital of Jingbian County,Yulin 718500,China)
出处
《临床医学研究与实践》
2019年第20期68-70,共3页
Clinical Research and Practice
关键词
小儿腹泻
双歧杆菌乳杆菌三联活菌片
蒙脱石散
infantile diarrhea
live combined bifidobacterium and lactobacillus tablets
montmorillonite powder
