摘要
目的探讨热疗联合注射用七叶皂苷钠治疗类肺炎性胸腔积液的临床效果及安全性。方法选择2016年7月~2018年7月河北省保定市第二中心医院收治的120例类肺炎性胸腔积液患者,采用随机数字表法将患者分为对照组(60例)和研究组(60例)。对照组给予注射用七叶皂苷钠治疗,研究组在对照组治疗的基础上联合给予深部热疗,两组均治疗2个疗程,5 d为1个疗程。评价并比较两组临床效果、胸腔积液吸收时间、退热时间及住院时间。比较两组治疗前后肺功能指标,包括用力肺活量(FVC)、第1秒用力呼气量(FEV1)情况。比较两组治疗过程中不良反应的发生情况。结果研究组的总有效率高于对照组,差异有统计学意义(P <0.05)。研究组胸腔积液吸收时间、退热时间及住院时间均明显短于对照组,差异均有统计学意义(均P <0.05)。两组治疗后FVC、FEV1较治疗前有明显的升高,且研究组升高程度大于对照组(P <0.05)。治疗过程中,两组不良反应发生率比较,差异无统计学意义(P> 0.05)。结论热疗联合注射用七叶皂苷钠对类肺炎性胸腔积液的治疗效果明显,能够缩短治疗时间,且安全性较好。
Objective To investigate the clinical efficacy and safety of hyperthermia combined with Aescinate Sodium for Injection in the treatment of pneumonia-like pleural effusion. Methods A total of 120 patients with pneumonic pleural effusion admitted to Baoding Second Central Hospital of Hebei Province from July 2016 to July 2018 were selected. The patients were divided into control group(60 cases) and research group(60 cases) by random number table method. The control group was treated with Sodium Aescinate for Injection, and the research group was combined with deep hyperthermia on the basis of the treatment in the control group. Both groups were given 2 courses of treatment,and 5 days was one course of treatment. The clinical effects, absorption time of pleural effusion, antipyretic time and hospitalization time in two groups were evaluated and compared. Pulmonary function indexes, including forced vital capacity(FVC) and forced expiratory volume in the first second(FEV1) were compared between the two groups before and after treatment. The adverse reactions during treatment were compared between the two groups. Results The total effective rate of the study group was higher than that of the control group, and the difference between the two groups was statistically significant(P < 0.05). The absorption time of pleural effusion, antipyretic time and hospitalization time in the research group were significantly shorter than those in the control group, and the differences were statistically significant(all P < 0.05). After treatment, FVC and FEV1 were significantly increased in the two groups compared with those before treatment, and the increase degree in the study group was greater than that in the control group(P < 0.05).During the treatment, there was no statistically significant difference in the incidence of adverse reactions between the two groups(P > 0.05). Conclusion Hyperthermia combined with Aescinate Sodium for Injection has obvious therapeutic effect on pneumonia-like pleural effusion, and can shorten the treatment time, with good safety.
作者
王紫汀
赵芳
姜国荣
王建
陈景
邰艳秒
孙砚诚
WANG Ziting;ZHAO Fang;JIANG Guorong;WANG Jian;CHEN Jing;TAI Yanmiao;SUN Yancheng(Department of Respiratory, Baoding Second Central Hospital, Hebei Province, Baoding 072750, China;the Second Department of Respiratory, Baoding Second Central Hospital, Hebei Province, Baoding 072750, China;CT Room, Baoding Second Central Hospital, Hebei Province, Baoding 072750, China)
出处
《中国医药导报》
CAS
2019年第18期113-116,共4页
China Medical Herald
基金
河北省卫生计生委医学科学研究重点课题计划项目(20150175)
河北省保定市科技计划项目(18ZF081)
关键词
类肺炎性胸腔积液
热疗
注射用七叶皂苷钠
效果
安全性
Parapneumonic effusions
Heat treatment
Aescinate Sodium for Injection
Efficacy
Safty
