摘要
目的:探究补肾养血安胎汤联合左甲状腺素钠片对妊娠期合并甲状腺功能减退患者的影响。方法:选取妊娠期合并有甲状腺功能减退的患者94例,按随机数字表法分为治疗组和对照组各47例。对照组采用左甲状腺素钠片治疗,治疗组在对照组基础上加用补肾养血安胎汤治疗。观察并比较2组患者疗效,治疗前后2组患者妊娠期血脂指标水平、甲状腺功能指标水平和妊娠激素水平,妊娠期并发症的发生情况。结果:治疗前,2组游离三碘甲状腺原氨酸(FT3)、游离甲状腺激素(FT4)、促甲状腺激素(TSH)水平比较,差异无统计学意义(P> 0.05)。治疗后,2组FT3、FT4水平较治疗前升高,TSH水平较治疗前降低;且治疗组FT3、FT4水平高于对照组,TSH水平低于对照组;差异均有统计学意义(P <0.05)。治疗前,2组人绒毛膜促性腺激素(HCG)、孕酮(P)、雌二醇(E2)水平比较,差异无统计学意义(P> 0.05)。治疗后,2组HCG、P、E2较治疗前升高,且治疗组高于对照组,差异均有统计学意义(P <0.05)。治疗前,2组总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)水平比较,差异无统计学意义(P> 0.05)。治疗后,治疗组TC、TG和LDL-C水平较治疗前显著降低,且低于对照组(P <0.05),HDL-C水平较治疗前显著提高,且明显高于对照组(P <0.05);对照组TG、LDL-C较治疗前降低(P <0.05)。治疗组总有效率为89.36%,显著高于对照组的68.09%,差异有统计学意义(P <0.05)。结论:补肾养血安胎汤联合左甲状腺激素钠片能有效改善妊娠期合并甲状腺功能减退患者的甲状腺功能、降低血脂水平、改善妊娠激素水平,治疗效果满意且安全有效,值得临床推广使用。
Objective: To observe the clinical effect of Bushen Yangxue Antai tang combined with levothyroxine sodium tablets for patients with hypothyroidism during pregnancy. Methods: A total of 94 patients with hypothyroidism during pregnancy were selected and divided into the treatment group and the control group according to the random number table method,47 cases in each group. The control group was treated with levothyroxine sodium tablets,and the treatment group was treated with Bushen Yangxue Antai tang based on the treatment of the control group. The therapeutic effect,the levels of blood lipid, thyroid function and hormones during pregnancy and the incidence of pregnancy complications in the two groups were observed and compared before and after treatment. Results: Before treatment, there was no statistically significant differences in the comparison of levels of free triiodothyronine(FT3), free thyroxine(FT4) and thyroid-stimulating hormone(TSH) between the two groups(P > 0.05). After treatment, the levels of FT3 and FT4 in the two groups were increased when compared with those before treatment,and the levels of TSH were decreased;the levels of FT3 and FT4 in the treatment group were higher than those in the control group, and the level of TSH was lower than that in the control group,differences being significant(P < 0.05). Before treatment,there was no significant difference in the comparison of the levels of human chorionic gonadotropin(HCG), progesterone(P) and estradiol(E2) between the two groups(P > 0.05). After treatment,levels of HCG,P and E2 in the two groups were increased when compared with those before treatment,and the above levels in the treatment group were higher than those in the control group, differences being significant(P < 0.05).Before treatment, there was no significant difference in the comparison of the levels of total cholesterol(TC), triglyceride(TG),low-density lipoprotein cholesterol(LDL-C) and high-density lipoprotein cholesterol(HDL-C) between the two groups(P > 0.05). After treatment,levels of TC,TG and LDL-C in the treatment group were significantly decreased when compared with those before treatment,and lower than those in the control group(P < 0.05);HDL-C level in the treatment group was significantly increased when compared with that before treatment,and was significantly higher than that in the control group(P < 0.05). In the control group,levels of TG and LDL-C were decreased when compared with those before treatment(P <0.05). The total effective rate in the treatment group was 89.36%, significantly higher than that of 68.09% in the control group, the difference being significant(P < 0.05). Conclusion: The therapy of Bushen Yangxue Antai tang combined with levothyroxine sodium tablets,can effectively improve the thyroid function of patients with hypothyroidism during pregnancy,reduce the level of blood lipid and improve the level of pregnancy hormones. The treatment effect is satisfactory,safe and effective, which is worthy of clinical promotion and use.
作者
朱太彩
张水荣
谷青青
刘俊华
ZHU Taicai;ZHANG Shuirong;GU Qingqing;LIU Junhua
出处
《新中医》
CAS
2019年第7期186-189,共4页
New Chinese Medicine
基金
河南省中医药管理局科研项目(2018ZY3004)
