摘要
目的探讨联合检测血清促卵泡生长激素(FSH)、抑制素B(INHB)对于预测无精症患者实施睾丸精子获取术(TESE)检测结局的价值。方法选取2016年3月-2017年1月在本院生殖健康门诊接受TESE检测的90例无精子症患者作为疾病组、90例健康男性作为对照组,并根据TESE检测结果分为成功组49例(成功获取生精细胞)、失败组41例(未能获取生精细胞),对比各组研究对象的FSH、INHB等指标,并采用受试者工作曲线分析FSH、INHB单独或者联合应用预测TESE检测结局的价值。结果选取血清FSH临界值水平为7.7 IU/L时,对应的预测TESE取精成功的灵敏度为66.18%、特异度为74.89%、AUC值为0.712;选取血清INHB临界值水平为36.2 pg/ml时,对应的预测TESE取精成功的灵敏度为82.31%、特异度为88.64%、AUC值为0.839;FSH及INHB联合应用时,对应的预测TESE取精成功的灵敏度为93.56%、特异度为90.77%、AUC值为0.918。结论 FSH及INHB联合应用对于预测TESE检测无精症患者取精成功率具有一定的临床价值。
Objective To investigate the combine detection value of serum follicle stimulating hormone(FSH) and inhibin B(INHB) in predicting the outcome of testicular sperm retrieval(TESE) in azoospermia patients.Methods 90 patients with azoospermia who received TESE at the reproductive health clinic from March 2016 to January 2017 were selected as the case group and 90 healthy men as the control group.According to the TESE test results,the objects were divided into success group(49 patients who received spermatogenic cells) and failure group(41 cases who fail to obtain spermatogenic cells).Comparing the FSH,INHB and other indicators of each group,and the receiver working curve was used to analyze the alone or combined detections of FSH,INHB in predicting the outcome of TESE test.Results When the serum FSH threshold value was set as 7.7 IU/L,the sensitivity of TESE sperm retrieval was 66.18%,the specificity was 74.89%,and the AUC value was 0.712.When the serum INHB threshold value was 36.2 pg/ml,The sensitivity of TESE sperm extraction was 82.31%,the specificity was 88.64%,and the AUC value was 0.839.When FSH and INHB were combined,the sensitivity of TESE sperm extraction was 93.56%,the specificity was 90.77%,and the AUC value was 0.918.Conclusion The combined use of FSH and INHB has a certain clinical value in predicting the success rate of sperm extraction in azoospermia patients by TESE.
作者
陈恒
江立千
张燕
李亚东
CHEN Heng;JIANG Li-qian;ZHANG Yan;LI Ya-dong(Clinical Laboratory,Shengde Hospital,Xinvang,Henan 464100,China)
出处
《中国卫生检验杂志》
CAS
2019年第13期1582-1584,共3页
Chinese Journal of Health Laboratory Technology
关键词
促卵泡生长激素
抑制素B
无精症
睾丸精子获取术
Follicle stimulating hormone
Inhibin B
Azoospermia
Testicular sperm retrieval
