摘要
妊娠糖尿病以糖耐量降低和胰岛素抵抗为特征,妊娠相关不良事件发生率高.microRNA是一组可调控基因表达的内源性小片段非编码RNA.妊娠糖尿病差异表达的胎盘microRNA可能与细胞增殖、迁移、分化、滋养层血管生成以及炎性反应有关.一些胎盘microRNA可经外泌体等途径进入母体血液循环中,差异表达的循环microRNA可能通过影响胰岛素分泌和转运通路、炎性反应、胎儿神经元分化、细胞增殖等相关基因的表达,参与妊娠糖尿病以及不良妊娠结局的发生和进展.因此,通过检测差异表达的microRNA可能发现早期预测妊娠糖尿病潜在的生物标志物.
Gestational diabetes mellitus (GDM) is characterized by decreased glucose tolerance and insulin resistance,which may result in high incidence of pregnancy-related adverse events.MicroRNA is a class of small endogenous noncoding RNA demonstrated to modulate gene expression.Differentially expressed placental microRNAs in GDM may be related to cell proliferation,migration,trophoblast angiogenesis and inflammation.Some placental microRNAs are released into maternal circulation via exosomes,and differentially expressed circulating microRNAs may affect the related gene expression involved ininsulin secretion and transport pathways,inflammatory response,fetal neuronal differentiation and cell proliferation,which may participate in the occurrence and progress of GDM and its adverse pregnancy outcomes.Therefore,the detection of differentially expressed microRNAs in patients with GDM may reveal potential biomarkers for early prediction of GDM.
作者
郑妙艳
石文琦
张美琳
单春艳
Zheng Miaoyan;Shi Wenqi;Zhang Meilin;Shan Chunyan(Department of Diabetic Nephropathy,NHC Key Laboratory of Hormones and Development(Tianjin Medical University),Tianjin Key Laboratory of Metabolic Diseases,The Metabolic Diseases Hospital&Tianjin Institute of Endocrinology,Tianjin Medical University,Tianjin 300070,China;School of Public Health,Tianjin Medical University,Tianjin 300070,China)
出处
《国际内分泌代谢杂志》
2019年第4期272-275,共4页
International Journal of Endocrinology and Metabolism
