摘要
近年研究表明,氧化应激损伤在脑缺血再灌注损伤中起重要作用.近来,大量研究报道大黄及其活性成分对脑缺血再灌注损伤具有脑保护作用,其作用机制与抗氧化作用密切相关,但其涉及的研究较多,如大黄酚、大黄素、大黄素甲醚、芦荟大黄素、大黄酸等,具体机制尚不清楚.为此,本文从抗氧化方面总结大黄游离蒽醌类成分对脑缺血再灌注损伤的脑保护机制,以期为临床运用和进一步研究提供参考.
Recent studies results showed that oxidative stress injury plays an important role in cerebral ischemia reperfusion injury.A large number of studies demonstrated that Rheum L.and its bioactive components have brain protection effects against cerebral ischemia reperfusion injury.The mechanisms is closely related to antioxidant effect,including rhein,chrysophanol,aloe-emodin,physcion,and emodin.However,the specific mechanism is still unclear.To provide reference for clinical application and further research,this paper summarized the protection mechanism of free anthraquinones from Rheum L.against cerebral ischemia reperfusion injury.
作者
蔡友德
何前松
樊梓媛
胡斐然
郭青
CAI Youde;HE Qiansong;FAN Ziyuan;HU Feiran;GUO Qing(Graduate School of Guizhou University of Traditional Chinese Medicine,Guiyang 550002, Guizhou China;The Second Clinical Medical College, Guizhou University of Traditional Chinese Medicine,Guiyang 550003, Guizhou China)
出处
《贵阳中医学院学报》
2019年第4期5-10,共6页
Journal of Guiyang University of Chinese Medicine
基金
贵州省科学技术基金,项目编号:黔科合基础[2016]1009
关键词
脑缺血再灌注损伤
大黄游离蒽醌
抗氧化
脑保护
Cerebral ischemia reperfusion injury
free anthraquinone
antioxidant activity
Rheum L Brain protection
