摘要
探讨3-硝基酪氨酸(3-NT)水平与新诊断2型糖尿病患者颈动脉粥样硬化的相关性。选取2017年2月至2017年12月于唐山工人医院内分泌科就诊的新诊断2型糖尿病患者96例作为研究对象,根据颈动脉超声检查结果将其分为颈动脉粥样硬化组(CAS组,n=54)和非颈动脉粥样硬化组(NCAS组,n=42)。同时从医院健康体检中心选取非糖尿病健康人群51名作为正常对照组(NC组)。收集其人口学资料及临床检验结果,采用酶联免疫吸附法(ELISA)检测血清3-NT水平。结果显示:(1)3组间3-NT水平比较,CAS组和NCAS组均高于NC组,CAS组高于NCAS组(均P<0.05);(2)在2型糖尿病患者中,3-NT与HbA1C、低密度脂蛋白胆固醇均呈正相关(均P<0.05);(3)在2型糖尿病患者中,经logistic回归分析发现,年龄(OR=1.271, P=0.023)、HbA1C (OR=1.812, P=0.005)、Hcy(OR=1.194, P=0.019)、3-NT(OR=1.593, P=0.011)均为颈动脉粥样硬化发生的危险因素。新诊断2型糖尿病患者血清3-NT与颈动脉粥样硬化相关,提示3-NT可能参与了颈动脉粥样硬化的发生及发展。
To investigate the association of serum 3-nitrotyrosine (3-NT) with carotid atherosclerosis in newly diagnosed type 2 diabetic patients. 96 patients with newly diagnosed type 2 diabetes mellitus treated in the department of endocrinology of Tangshan Gongren Hospital were recruited, and were divided into two groups depending on their carotid atherosclerosis status as carotid atherosclerosis group (CAS group, n=54) and non-carotid atherosclerosis group (NCAS group, n=42);while 51 healthy subjects without type 2 diabetes mellitus from the medical examination center were recruited as normal control group (NC group, n=51). Demographic and clinical data of all subjects were collected. Serum 3-NT levels were measured by Enzyme-Linked Immunosorbent Assay (ELISA).(1) The levels of 3-NT in CAS group and NCAS group were all higher than those in NC group, and the level of 3-NT in CAS group was higher than that in NCAS group (all P<0.05);(2) In type 2 diabetic patients, 3-NT was positively correlated with HbA1C and low density lipoprotein-cholesterol (both P<0.05);(3) Logistic regression analysis showed that age (OR=1.271, P=0.023), HbA1C (OR=1.812, P=0.005), Hcy (OR=1.194, P=0.019), and 3-NT (OR=1.593, P=0.011) were risk factors of CAS in type 2 diabetic patients. Serum 3-NT was closely correlated with carotid atherosclerosis in newly diagnosed type 2 diabetic patients, suggesting that serum 3-NT may be involved in the carotid atherosclerosis of newly diagnosed type 2 diabetic patients.
作者
安彩霞
房辉
杨岳
An Caixia;Fang hui;Yang Yue(Department of Endocrinology, Tangshan Gongren Hospital, Hebei Medical University, Tangshan 063000, China)
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2019年第6期491-493,共3页
Chinese Journal of Endocrinology and Metabolism
关键词
3-硝基酪氨酸
新诊断
糖尿病
2型
颈动脉粥样硬化
3-nitrotyrosine
Newly diagnosed
Diabetes mellitus, type 2
Carotid atherosclerosis
