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天葵子化学成分及抑菌活性研究 被引量:9

Studies on chemical constituents and antibacterial activity of Semiaquilegia adoxoides
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摘要 为探究天葵子化学成分及其抑菌活性。采用色谱法从天葵子中分离得到13个化合物,利用波谱学等方法鉴定了它们的化学结构,分别鉴定为蝙蝠葛内酯(1)、格列风内酯(2)、β-谷甾醇(3)、胡萝卜苷(4)、对羟基苯乙醇(5)、邻苯二甲酸-二-2-乙基-己酯(6)、小檗碱(7)、木兰碱(8)、唐松草酚定(9)、果糖(10)、紫草氰苷(11)、小檗红碱(12)、bauhinin(13)。其中化合物12和13为首次从天葵子中分离得到。采用滤纸片琼脂扩散法测定了所得化合物的抑菌活性,其中化合物7和12具有明显的抑菌活性,在载药量为5μg/片时,化合物7对白菜软腐病菌和猕猴桃溃疡病菌的抑菌圈直径分别为19.4、13.3mm;化合物12对青枯病菌和猕猴桃溃疡病菌的抑菌圈直径分别为13.2、12.8mm,表明天葵子对于防治作物细菌性病害具有较好的应用前景。 This reaserch aimed to explore the chemical constituents and antibacterial activity of Semiaquilegia adoxoides. Thirteen compounds were isolated from the root of Semiaquilegia adoxoides .Their structures were identified as menisdaurilide ( 1),griffonilide (2),β- sitosterol (3),daucosterol (4), p -hydroxybenzyl ethanol (5 ), bis (2-ethylhexyl) phthalate ( 6),berberine (7),magnoflorine (8),thalifendine (9),fructose (10),lithospermoside (11),berberrubine (12),bauhinin (13),respectively,mostly by sepectroscopic.Compound 12 and 13 were isolated from Semiaquilegia adoxoides for the first time.In addition,the antibacterial activity of each compound of Semiaquilegia adoxoides was evaluated by paper disc diffusion method.As a result,compound 7 and 12 showed obvious antibacterial activity.At 5 μg/disc,the diameter of inhibition zone of Compound 7 against Erwinia carotovora pv. Carotovora and Pseudomonas syringae pv. Actinidiae were 19.4 mm and 13.3 mm,respectively,and the diameter of inhibition zone of Compound 12 against Ralstonia solanacearum and Pseudomonas syringae pv. Actinidiae were 13.2 mm and 12.8 mm.The results showed that Semiaquilegia adoxoides had good application prospects in controlling bacterial diseases of crops.
作者 刘学勇 姬志勤 LIU Xue-yong;JI Zhi-qin(College of Plant Protection,Northwest A&F University;Shaanxi Province Key Laboratory Research & Development on Botanical Pesticides,Yangling 712100 ,China)
出处 《天然产物研究与开发》 CAS CSCD 北大核心 2019年第7期1177-1182,共6页 Natural Product Research and Development
基金 国家重点研发计划(2017YFD0201402) 陕西省教育厅重点实验室科研计划(13JS008)
关键词 天葵子 小檗碱 抑菌活性 分离鉴定 Semiaquilegia adoxoides berberine antibacterial activity isolation and identification
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