摘要
目的:比较舒芬太尼与芬太尼用于危重症儿童镇痛、镇静的疗效,为临床用药提供参考.方法:回顾性选取2018年1-6月惠州市妇幼保健计划生育服务中心儿童重症监护病房使用芬太尼的患儿101例作为对照组,2018年7-12月使用舒芬太尼的患儿99例作为观察组.观察两组患儿镇痛前后的生命体征、肝功能指标水平、肾功能指标水平及血气分析指标水平,并比较两组患儿镇痛效果和不良反应发生情况的差异.结果:镇痛后,两组患儿心率、呼吸频率、平均动脉压及脉搏血氧饱和度的差异均无统计学意义(P>0.05);两组患儿天门冬氨酸氨基转移酶、丙氨酸氨基转移酶、总胆红素、白蛋白及总蛋白水平的差异均无统计学意义(P>0.05);两组患儿肌酐、尿素氮水平的差异均无统计学意义(P>0.05);两组患儿动脉血二氧化碳分压、动脉血氧分压水平的差异均无统计学意义(P>0.05).给药第3日,观察组、对照组患儿的镇痛达标率分别为47.5%(47/99)、48.5%(49/101),镇静达标率分别为20.2%(20/99)、18.8%(19/101),差异均无统计学意义(P>0.05).观察组、对照组患儿的不良反应发生率分别为13.1%(13/99)、14.9%(15/101),差异无统计学意义(P>0.05);但观察组患儿的低血压发生率为1.0%(1/99),明显低于对照组的5.0%(5/101),差异有统计学意义(P<0.05).结论:舒芬太尼与芬太尼用于危重症儿童的镇痛效果相近,但应用舒芬太尼的患儿低血压发生率较低.
OBJECTIVE:To compare the analgesic and sedative effects between sufentanil and fentanyl in critically ill children,so as to provide references for clinical use of drugs.METHODS:101 children with application of fentanyl admitted into PICU in Huizhou Maternal and Child Health Family Planning Service Center in Jan.-Jun.2018 were retrospectively selected as the control group,another 99 children with application of sufentanil in Jul.-Dec.2018.The vital signs,indices of liver function,renal function and blood gas analysis of the two groups before and after analgesia were observed,differences in analgesic effect and incidence of adverse drug reactions between two groups were compared.RESULTS:After analgesia,there were no statistical significance in differences of heart rates,respiratory rates,mean arterial pressure and saturation of pulse oximetry between two groups(P>0.05);there were no statistical significance in differences of aspartate aminotransferase,alanine aminotransferase,total bilirubin,albumin and total protein levels between two groups(P>0.05);there were no statistical significance in differences of creatinine and urea nitrogen levels between two groups(P>0.05);there were no statistical significance in differences of partial pressure of carbon dioxide in artery and arterial partial pressure of oxygen levels between two groups(P>0.05).At the 3rd day of administration,the control rates of analgesia of observation group and control group were respectively 47.5%(47/99)and 48.5%(49/101),the control rates of sedation of observation group and control group were respectively 20.2%(20/99)and 18.8%(19/101),the differences had no statistical significance(P>0.05).The incidences of adverse drug reactions of observation group and control group were respectively 13.1%(13/99)and 14.9%(15/101),the difference had no statistical significance(P>0.05);while the incidence of hypotension of observation group was 1.0%(1/99),which was significantly lower than that of the control group(5.0%,5/101),with statistically significant difference(P<0.05).CONCLUSIONS:Sufentanil has similar analgesic and sedative effects with fentanyl in critically ill children,while the incidence of hypotension is lower in children with application of sufentanil.
作者
刘燕好
廖世雄
李楚云
陈美玲
唐尚鸿
LIU Yanhao;LIAO Shixiong;LI Chuyun;CHEN Meiling;TANG Shanghong(Dept.of Pharmacy,the First Maternal and Child Health Hospital of Huizhou,Guangdong Huizhou 516001,China;Dept.of Pharmacy,People’s Hospital of Huizhou,Guangdong Huizhou 516001,China;Child Intensive Care Unit,Huizhou Maternal and Child Health Family Planning Service Center,Guangdong Huizhou 516001,China)
出处
《中国医院用药评价与分析》
2019年第7期846-848,852,共4页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
舒芬太尼
芬太尼
危重症
儿童
镇痛/镇静
Sufentanil
Fentanyl
Critical ill
Children
Analgesia/sedation
