摘要
目的 探讨壁冠状动脉对急性心肌梗死患者血清炎性因子水平及血管狭窄程度的影响.方法 急性心肌梗死患者657例,其中合并壁冠状动脉327例为观察组,未合并壁冠状动脉330例为对照组,比较2组病变血管支数,SYNTAX积分,血沉、白细胞计数、血小板/淋巴细胞比值以及血清尿酸、总胆固醇、三酰甘油、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、心肌肌钙蛋白Ⅰ、同型半胱氨酸、C反应蛋白、D-二聚体水平.结果 观察组3支血管病变比率(52.3%)、SYNTAX积分[(23.20±3.80)分]、白细胞计数[(13.09±2.09)×109/L]、血小板/淋巴细胞比值(189.84±9.60)以及血清同型半胱氨酸[(16.80±1.76)μmol/L]、C反应蛋白[(20.31±0.18) mg/L]、D-二聚体(1.16±0.17) mg/L]水平较对照组[40.0%、(17.90±4.78)分、(11.16±9.02)× 109/L、150.35±1.80、(13.03±1.68) μmol/L、(12.81±0.29)mg/L、(0.85±0.18)mg/L]增高(P<0.05),血沉[(30.70±6.07)mm/h]较对照组[(22.90±3.53) mm/h]增快(P<0.05),血清尿酸[(457.12±67.56)μmol/L]、心肌肌钙蛋白Ⅰ[(141.11±3.92) ng/L]、总胆固醇[(5.57±0.65) mmol/L]、三酰甘油[(2.01±0.37) mmol/L]、高密度脂蛋白胆固醇[(2.29±0.31) mmol/L]、低密度脂蛋白胆固醇[(3.03±0.42)mmol/L]水平与对照组[(398.21±86.51)μmol/L、(140.81±2.87)ng/L、(5.72±0.95) mmol/L、(2.11±0.57)mmol/L、(2.31±0.59) mmol/L、(3.09±0.39)mmol/L]比较差异无统计学意义(P>0.05).结论 壁冠状动脉可能加剧急性心肌梗死炎性反应,加重血管狭窄程度.
Objective To study the influence of mural coronary artery on the levels of serum inflammatory cytokines and vessel stenosis degree in patients with acute myocardial infarction(AMI). Methods Totally 657 patients with AMI were divided into 327 patients with mural coronary artery(observation group) and 330 patients without mural coronary artery(control group). The diseased vessel count, SYNTAX score, erythrocyte sedimentation rate, white blood cell count, platelet/lymphocyte ratio, serum uric acid, total cholesterol, triacylglycerol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, cardiac troponin I, homocystein, C-reactive protein and D-dimer level were detected and compared between two groups. Results The proportion of triple vessel disease(52.3%), SYNTAX score(23.20±3.80), white blood cell count((13.09±2.09)×10~9/L), platelet/lymphocyte ratio(189.84±9.60), homocystein((16.80±1.76) μmol/L), C-reactive protein((20.31±0.18) mg/L) and D-dimer((1.16±0.17) mg/L) in observation group were significantly higher than those in control group(40.0%, 17.90±4.78,(11.16±9.02)×10~9/L, 150.35±1.80,(13.03±1.68) μmol/L,(12.81±0.29) mg/L,(0.85±0.18) mg/L)(P<0.05), erythrocyte sedimentation rate((30.70±6.07) mm/h) was significantly quicker than that in control group((22.90±3.53) mm/h)(P<0.05), and serum uric acid((457.12±67.56) μmol/L), cardiac troponin I((141.11±3.92) ng/L), total cholesterol((5.57±0.65) mmol/L), triacylglycerol((2.01±0.37) mmol/L), high-density lipoprotein cholesterol((2.29±0.31) mmol/L) and low-density lipoprotein cholesterol((3.03±0.42) mmol/L) showed no significant differences compared with those in control group((398.21±86.51) μmol/L,(140.81±2.87) ng/L,(5.72±0.95) mmol/L,(2.11±0.57) mmol/L,(2.31±0.59) mmol/L,(3.09±0.39) mmol/L)(P>0.05). Conclusion Mural coronary artery may aggravate the inflammatory response and the degree of vascular stenosis in patients with AMI.
作者
陈明
谭强
CHEN Ming;TAN Qiang(^Department of Cardiology ,the First Hospital of Qinhuangdao, Qinhuangdao 066000,China)
出处
《中华实用诊断与治疗杂志》
2019年第7期688-690,共3页
Journal of Chinese Practical Diagnosis and Therapy
基金
河北省科技支撑项目(16277720D)
