摘要
目的:研究分析卡泊芬净治疗重症患者侵袭性真菌感染的疗效与安全性。方法:将2015年~2017年收治的侵袭性真菌感染的重症患者48例按照数字随机法分成两组,对照组实施常规伊曲康唑治疗,观察组患者卡泊芬净治疗,比较两组患者的治疗效果以及治疗期间不良反应发生情况比较。结果:观察组患者治疗又总有效率为83.33%(40/24),较比对照组62.5%(15/24)的治疗有效率有差异(P<0.05),有统计学意义;观察组患者治疗期间不良反应发生率为16.67%(4/24),较比对照组29.17%(7/24)的发生率有差异(P<0.05),有统计学意义。结论:重症患者侵袭性真菌感染采用卡泊芬净治疗的效果较好,不良反应少,安全性高,能有效降低临床死亡率,值得临床推广。
Objective: To study the efficacy and safety of caspofungin in the treatment of patients with severe invasive fungal infections. Methods: 48 patients with invasive fungal infections admitted in a hospital from 2015 to 2017 were randomly divided into two groups. Patients in the control group were treated with itraconazole and those in the observation group were treated with caspofungin, the therapeutic effect and adverse reactions during treatment of two groups were compared. Results: The total effective rate of treatment in the observation group was 83.33%(40/24), which was significantly higher than that in the control group with 62.5%(15/24)(P<0.05). The incidence of adverse reactions during treatment in the observation group was 16.67%(4/24), which was significantly higher than that in the control group 29.17%(7/24)(P<0.05). Conclusion: The treatment of carpofen in treating severe invasive fungal infection is more effective, with less adverse reactions and higher safety, cab effectively reduce the clinical mortality, which is worthy of clinical promotion.
作者
段杏华
Duan Xinghua(Department of Intensive Medicine, Huiyang Sanhe Hospital, Guangdong Province, Huizhou 516211)
出处
《数理医药学杂志》
2019年第8期1202-1203,共2页
Journal of Mathematical Medicine
