摘要
鸢尾素(irisin)是一种运动诱导骨骼肌分泌的肌肉因子,是由Ⅲ型纤连蛋白组件包含蛋白5 (fibronectin type Ⅲ-domain containing protein 5, FNDC5)剪切、修饰后分泌到血液中的多肽性片段。鸢尾素可以使白色脂肪棕色化,增加机体能耗,减轻体重。鸢尾素在糖尿病、冠心病等多种疾病的代谢过程中发挥着重要的作用,不同类型的运动对血液循环中鸢尾素水平的影响不同,而适度运动可以减轻心血管疾病症状。本文对鸢尾素的心血管保护作用及其在运动领域的研究进展作一综述,以期为心血管疾病的预防和治疗提供新的靶点。
Irisin is a circulating myokine induced by exercise, which is a cleaved version of fibronectin type Ⅲ domain containing protein 5(FNDC5). It can promote the browning of white fat tissue, increase energy consumption, and decrease weight. Irisin plays an important role in the regulation of various diseases, such as diabetes and coronary heart disease. Different types of exercise have different effects on irisin level in blood circulation, and moderate exercise can reduce cardiovascular symptoms. In this paper, the cardiovascular protective effect of irisin and its research progress in the field of exercise are reviewed, hoping to provide a new target for the prevention and treatment of cardiovascular diseases.
作者
王珅
廖静雯
尹洪刚
季慧慧
俞杭
邹宇豪
胡敏
WANG Shen;LIAO Jing-Wen;YIN Hong-Gang;JI Hui-Hui;YU Hang;ZOU Yu-Hao;HU Min(Department of Sports and Health,Guangzhou Sport University,Guangzhou 510500,China;Scientific Research Center,Guangzhou Sport University,Guangzhou 510500,China;Medical School of Ningbo University,Ningbo 315000,China)
出处
《生理学报》
CAS
CSCD
北大核心
2019年第3期478-484,共7页
Acta Physiologica Sinica
基金
supported by the National Natural Science Foundation of China (No.31771315)
关键词
鸢尾素
心血管疾病
运动
血管内皮障碍
irisin
cardiovascular disease
exercise
endothelial dysfunction
