摘要
目的研究血清血脂指标、血糖指标及一般病史(性别、年龄、身高、体重、高血压病史、糖尿病史、胃息肉、脂肪肝、吸烟史、饮酒史)与结直肠息肉发病的相关关系,并建立结直肠息肉高危人群早期筛查评分模型。方法回顾性分析2017年1月~2018年5月就诊于徐州医科大学附属医院消化内科的592例患者的临床资料(其中有息肉者为实验组,共306例,无息肉者为对照组,共286例),包括血清血脂指标、血糖指标及一般病史资料,并对各因素进行统计学分析,确定差异有统计学意义的危险因素,进行二元Logistic回归分析,进而得出相应自变量的回归系数,由此建立早期筛查评分模型。结果通过研究确定年龄>50岁,糖尿病史、吸烟史、肥胖、高胆固醇水平、高甘油三酯水平与结直肠息肉的发病相关,并建立评分模型,根据两组各受试者评分绘制ROC曲线,曲线下面积(AUG)为0.731(标准误0.02,渐进显著性P=0.000,置信区间0.691~0.771)。结论本研究得出结直肠息肉的独立危险因素包括:年龄>50岁、糖尿病史、吸烟史、肥胖、高胆固醇水平及高甘油三酯水平,并由此建立的结直肠息肉高危人群早期筛查评分模型对结直肠息肉高危人群的早期筛查具有一定效果。
Objective To study the correlation between serum lipid index,blood sugar index and general medical history (sex,age,height,weight,history of hypertension,diabetes mellitus,history of gastric polyps,fatty liver,smoking and drinking) and the incidence of colorectal polyps,and to establish an early screening scoring model for high-risk groups of colorectal polyps.Methods A retrospective analysis was made of the clinical data of 592 patients who were admitted to the Department of Gastroenterology,Affiliated Hospital of Xuzhou Medical University from January 2017 to May 2018 (306 with polyps and 286 without polyps) including serum lipid index,blood sugar index and general medical history data.The factors were analyzed by statistics,and the risk factors with statistical significance were determined.The binary Logistic regression analysis was carried out,and the regression coefficients of the corresponding independent variables were obtained,thus the early screening scoring model was established.Results Through the study,we determined that age over 50 years old,diabetes mellitus,smoking history,obesity,high cholesterol level,high triglyceride level were related to the incidence of colorectal polyps,and established a scoring model.According to the scores of the two groups of subjects,ROC curve was drawn.The area under the curve (AUG) was 0.731(standard error 0.02,progressive significance P =0.000,confidence interval 0.691-0.771).Conclusion Independent risk factors for colorectal polyps included age over 50,history of diabetes mellitus,smoking history,obesity,high total cholesterol levels and high triglyceride levels.The established early screening scoring model for high-risk groups of colorectal polyps has certain effect on early screening of high-risk groups of colorectal polyps.
作者
吕莹莹
朱炳喜
Lv Yingying;Zhu Bingxi(Xuzhou Medical University,Jiangsu 221000,China)
出处
《医学研究杂志》
2019年第8期132-136,共5页
Journal of Medical Research
关键词
结直肠息肉
高危人群
筛查
评分模型
Colorectal polyps
High-risk groups
Screening
Scoring model
