摘要
目的:观察补阳蠲痹汤联合臭氧注射治疗急性腰椎退行性关节炎的临床疗效及对患者血清炎性因子的影响。方法:选取98例患者作为观察对象,依据随机数字表法均分后纳入对照组与研究组,每组各49例。对照组行臭氧注射治疗,研究组行补阳蠲痹汤联合对照组疗法;1个疗程后,对比两组临床疗效,观察两组患者治疗前、后主要中医证候积分、疼痛程度、腰部功能障碍、腰椎整体功能、血清炎性因子与基质金属蛋白酶-3(MMP-3)、骨形态发生蛋白(BMP-7)表达的变化情况;随访1年,统计两组复发情况。结果:治疗后,两组患者主要中医证候积分、疼痛程度、腰部功能障碍、腰椎整体功能、血清炎性因子与MMP-3、BMP-7均显著下降(P<0.05),观察组均显著低于对照组(P<0.05);观察组全部患者总有效率95.92%,对照组79.59%,观察组临床疗效优于照组(P<0.05);治疗1年后观察组复发率为6.12%,对照组为22.45%,观察组复发率低于对照组(P<0.05)。结论:臭氧注射治疗急性腰椎退行性关节炎疗效确切,联合补阳蠲痹汤后可提高临床疗效整体水平,更为有效的抑制炎性反应、减少软骨基质降解、缓解相关症状并改善腰椎功能,可降低复发概率。
Objective:To observe the curative effect of Buyang Yibi decoction combined ozone injection in treatment of acute lumbar degenerative arthritis and its influence on serum inflammatory factors of patients. Methods:A total of 98 patients with acute lumbar degenerative arthritis were selected. All patients were divided into control group and research group randomly,49 patients in each group. The control group were treated with line control ozone injection,the research group were treated with Buyang Yibi decoction combined line control ozone injection on the basic of the control group. After one course of treatment,the clinical curative effect of the 2 groups were compared. The main TCM syndrome scores,pain degree,lumbar dysfunction,lumbar vertebra overall function,serum inflammatory factors,matrix metalloproteinase-3 (MMP-3) and bone morphogenetic protein (BMP-7) of the 2 groups were observed before and after treatment. After 1 year of follow-up,the recurrence of the 2 groups were counted. Results:After treatment,the main TCM syndromes scores,pain degree,lumbar dysfunction,lumbar vertebra overall function,serum inflammatory factors,MMP-3 and BMP-7 of the 2 groups were significantly decreased (all P <0.05),and the observation group was significantly lower than the control group ( P <0.05). The total effective rate was 95.92% in the observation group,and was 79.59% in the control group,the difference was statistically significant ( P <0.05). After 1 year of follow-up,the recurrence rate was 6.12% in the observation group,and was 22.45% in the control group,the difference was statistically significant ( P <0.05). Conclusion:Application of Buyang Yibi decoction combined ozone injection in treatment of acute lumbar degenerative arthritis can improve the clinical curative effect,it can effectively inhibit inflammatory reaction,reduce cartilage matrix degradation,alleviate related symptoms,improve the lumbar vertebral function,and reduce the probability of recurrence.
作者
黄岩石
褚青波
陈晓
周运峰
HUANG Yanshi;CHU Qingbo;CHEN Xiao(Department of Orthopaedics,Nanyang Second General Hospital(Nanyang 473000))
出处
《陕西中医》
2019年第8期1044-1048,共5页
Shaanxi Journal of Traditional Chinese Medicine
基金
河南省科技攻关计划项目(0624410033)
河南省教育厅自然科学研究计划项目(2007360038)
关键词
骨关节炎
脊柱
退行性病变
补阳蠲痹汤
臭氧注射
血清炎性因子
Osteoarthritis
Spine
Degeneration
Buyang Yibi decoction
Ozone injection
Serum inflammatory factors
