摘要
目的探讨宫腔灌注地塞米松对中重度宫腔粘连子宫内膜雌激素受体(E2R)、转化生长因子-β1(TGF-β1)及血管内皮生长因子(VEGF)的影响。方法选取2016年10月~2017年6月广东省深圳市南山区人民医院收治的中重度宫腔粘连患者120例作为研究对象,采用随机数字表法将其分为研究组及对照组,每组各60例。研究组给予地塞米松5mg+生理盐水10mL灌注膨宫10min,1次/d;对照组术后宫腔灌注等量生理盐水。观察两组人工治疗前后E2R、TGF-β1及VEGF水平变化。结果两组人工治疗1、3个月后总有效率比较,差异有统计学意义(P<0.05);研究组人工治疗3个月后总有效率高于同组人工治疗1个月后,差异有统计学意义(P<0.05)。两组人工治疗1、3个月后E2R、TGF-β1及VEGF水平均低于同组人工治疗前,且人工治疗3个月后低于人工治疗1个月后,差异有统计学意义(P<0.05);研究组人工治疗1、3个月后E2R、TGF-β1、VEGF水平均低于对照组,差异有统计学意义(P<0.05)。结论地塞米松可以改变子宫内膜样本中的E2R、TGF-β1及VEGF水平的表达,并可通过宫腔灌注辅助中重度宫腔粘连患者宫腔镜术后的治疗。
Objective To investigate the effect of intrauterine perfusion of Dexamethasone on the estradiol receptor (E2R),transfotruing growth factor-beta 1 (TGF-β1),vescular endothelial growth factor (VEGF) of endometrium with moderate and severe intrauterine adhesion.Methods From October 2016 to June 2017,120 patients with moderate and severe intrauterine adhesion in Nanshan District People′s Hospital of Shenzhen City,Guangdong Province were selected as the research objects,and they were divided into research group and control group by the random number group,with 60 cases in each group.The research group were given Dexamethasone 5 mg + normal saline 10 mL of perfusion palace 10 min;and the control group was perfused with the same amount of normal saline.The level changes of E2R,TGF-β1 and VEGF before and after artificial treatment were observed.Results There were statistically significant differences in the total effective treatment for 1 and 3 months after artificial treatment between the two groups (P < 0.05);the total effective rate of research group 3 months after artificial treatment was higher than that 1 month after artificial treatment,the difference was statistically significant (P < 0.05).The E2R,TGF-β1 and VEGF of the two groups 1 and 3 months of after artificial treatment were all lower than those before treatment of the same group,and those 3 months after artificial treatment were lower than 1 month after artificial treatment,the differences were statistically significant (P < 0.05).The E2R,TGF-β1 and VEGF of the research group 1 and 3 months after artificial treatment were all lower than those of the control group,the differences were statistically significant (P < 0.05).Conclusion Dexamethasone can alter the expression of E2R,TGF-β1 and VEGF in endometrium samples,and can assist in the post-hysteroscopic treatment of patients with moderate and severe intrauterine adhesion by intrauterine perfusion.
作者
魏舒
姚红
张玉翠
WEI Shu;YAO Hong;ZHANG Yucui(Department of Gynecology,Nanshan District People′s Hospital of Shenzhen City,Guangdong Province,Shenzhen 518052,China;Department of Gynecology,Nanshan District Shekou People′s Hospital of Shenzhen City,Guangdong Province,Shenzhen 518055,China)
出处
《中国医药导报》
CAS
2019年第20期108-111,共4页
China Medical Herald
基金
广东省深圳市南山区卫生和计划生育局项目(2016027)
关键词
宫腔灌注
地塞米松
中重度宫腔粘连
子宫内膜
雌二醇受体
角膜组织中转化生长因子-β1
血管内皮生长因子
Intrauterine perfusion
Dexamethasone
Moderate and severe intrauterine adhesion
Endometrium
Cytosolic estradiol receptor
Transfotruing growth factor-β1
Vescular endothelium growth factor
