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自体富血小板纤维蛋白治疗慢性伤口有效性与安全性的Meta分析 被引量:4

Efficacy and Safety of Autologous Platelet-Rich Fibrin in Treatment of Chronic Wounds:A Meta-analysis
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摘要 目的通过系统综述探讨富血小板纤维蛋白治疗慢性伤口的有效性及安全性。方法计算机检索PubMed、Medline、EMbase、CochraneLibrary、WebofScience、CNKI、CBM、Wan-Fangdata、VIP等原始数据,并补充检索了BestPractice、世界伤口治疗协会联盟、欧洲/美国压疮咨询小组、欧洲伤口管理协会、欧洲组织修复协会、国际伤口感染研究所以及中华医学会创伤学分会组织修复学组等伤口治疗专业网站,搜集关于富血小板纤维蛋白治疗慢性伤口的随机对照与类实验研究,检索时间均从建库至2018年12月。由2名研究员独立筛选及评价纳入研究质量及偏移风险,采用RevMan5.3进行Meta分析。结果共5个研究,206例患者被纳入。Meta分析显示:富血小板纤维蛋白组伤口愈合时间[MD=-15.47,95%CI(-16.36,-14.59),P<0.001];患者住院时间[MD=-12.36,95%CI(-16.34,-8.47),P<0.001];伤口治愈人数[OR=8.74,95%CI(2.97,25.68),P<0.001];伤口治疗有效人数[OR=7.89,95%CI(2.63,23.62),P<0.001]与对照组比较差异均有统计学意义。且纳入的所有研究试验组与对照组均未发生治疗相关不良事件。结论富血小板纤维蛋白能提高伤口愈合率,缩短患者住院时间,减少住院费用,不会增加不良事件发生风险。但受研究样本之间个体性差异影响,仍需更多高质量研究对其进行论证。 Objective To evaluate the efficacy and safety of platelet-rich fibrin (PRF) in the treatment of chronic wounds.Methods We retrieved PubMed,Medline,EMbase database,Cochrane Library,Web of Science,China Knowledge Network,China Biomedical Database,Wanfang database,and VIP by computer to collect randomized controlled trials (RCTs) and quasi-experimental studies about treatment of chronic wounds with PRF from its inception to December of 2018 and we meanwhile researched articles from some professional websites of chronic wound treatment including The Best Practice,World Wound Therapy Association,European/American Pressure Ulcer Advisory Group,European Wound Management Association,European Organizational Restoration Association,the International Wound Infection Research Institute and the Chinese Medical Association Trauma Branch,and Department of Prosthetics.Two research fellows worked independently and evaluated the quality and migration risk,and Meta integration was performed using RevMan 5.3 software.Results Five articles were included with 206 patients.Meta results show that in PRF group,wound healing time[MD=-15.47,95%CI(-16.36,-14.59),P<0.001],length of hospital stay[MD=-12.36,95%CI(-16.34,-8.47),P<0.001],number of patients with cured wound [OR=8.74,95%CI(2.97,25.68),P<0.001] and number of patients with effective treatment [OR=7.89,95%CI(2.63,23.62),P<0.001] were statistically significant.No treatment-related adverse events occurred in all studies.Conclusion PRF is effective for improving wound healing rate,shortening hospitalization time and reducing hospitalization cost.However,due to the individual differences between the study samples,more high-quality studies are needed.
作者 邓波 江波 陈静文 李显蓉 DENG Bo;JIANG Bo;CHEN Jing-wen;LI Xian-rong(School of Nursing,Southwest Medical University,Luzhou 646000,China;Dept.of Plastic Burns Surgery,Affiliated Hospital of Southwest Medical University,Luzhou 646000,China;Dept.of Gastrointestinal Surgery,Affiliated Hospital of Southwest Medical University,Luzhou 646000,China)
出处 《护理学报》 2019年第13期6-11,共6页 Journal of Nursing(China)
基金 泸州市科技计划项目[2017-S-40(1/18)]
关键词 富血小板纤维蛋白 慢性伤口 META分析 platelet-rich fibrin chronic wound Meta-analysis
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