摘要
目的探讨糖化血红蛋白和糖蛋白抗原15-3(CA15-3)水平与女性乳腺癌发病风险的关系。方法收集2016~2018年107例确诊为乳腺癌的女性患者,选取年龄相匹配的110例女性体检者为对照组,采用高效液相色谱法和化学发光法检测血清中HbA1c和CA15-3的水平,非条件Logistic回归分析其与乳腺癌的相关性。结果乳腺癌组HbA1c和CA15-3异常率分别为30.84%(33/107)和8.41%(9/107),对照组HbA1c和CA15-3异常率分别为23.64%(26/110)和2.73%(3/110),差异均有统计学意义(t=2.830,P=0.005;t=3.349,P=0.001)。回归分析显示,HbA1c和CA15-3异常患者发生乳腺癌的风险都显著升高(OR=1.332,95%CI=1.016~1.745;OR=1.047,95%CI=1.008~1.088)。结论高水平HbA1c和CA15-3是女性乳腺癌发生的危险因素。
Objective To evaluate the association of HbA1 c and CA15-3 levels with breast cancer risk in women of China.Methods A case-control study was performed with 107 breast cancer patients and 110 age-matched check-up controls collected from 2016 to 2018.The serum levels of HbA1 c and CA15-3 were measured by high performance liquid chromatography assay and chemiluminescence method respectively.Logistic regression analyses were performed to examine the relationship.Odds ratios(OR) and 95% confidence intervals(CI) were estimated.Results The prevalence of HbA1 c and CA15-3 in case group were 30.84%(33/107) and 8.41%(9/107),whereas the unusual rates of which were 23.64%(26/110) and 2.73%(3/110) respectively in the control group.The results were significantly different(t=2.830,P=0.005;t=3.349,P=0.001).Elevated HbA1 c and CA15-3 levels were significantly associated with increased breast carcinoma risk compared with the control group(OR=1.332,95%CI=1.016~1.745;OR=1.047,95%CI=1.008~1.088).Conclusion High levels of HbA1 c and CA15-3 would be risk factors for female breast cancer.
作者
靳庆娥
乌姗娜
张亚鑫
苏建荣
JIN Qing-e;WU Shan-na;ZHANG Ya-xin;SU Jian-rong(Department of Clinical Laboratory,Beijing Friendship Hospital of the Second Clinical Medical College of Capital Medical University,Beijing 100050,China)
出处
《现代检验医学杂志》
CAS
2019年第4期143-145,共3页
Journal of Modern Laboratory Medicine
