摘要
目的探讨西格列汀联合二甲双胍联合治疗老年2型糖尿病(T2DM)的临床疗效及安全性,为临床优化治疗提供相关参考。方法收集2016年6月至2018年12月内分泌科就诊的无严重急慢性并发症、老年2型糖尿病(T2DM)患者220例,按照患者入院就诊先后次序将其分为对照组100例和观察组120例。对照组口服常规药物二甲双胍500mg/次,3次/d。观察组在对照组基础上联合西格列汀治疗,100mg/次,1次/d,均持续治疗6个月。比较2组治疗前后空腹血糖(FBG)、餐后2h血糖(2hPG)、糖化血红蛋白(HbA1c)的表达差异,评估2组血糖控制效果及相关不良反应发生情况。结果2组患者均谨遵医嘱完成治疗,无中途退出或脱落病例。2组治疗后血糖指标FBG、2hPG、HbAlc较治疗前均有显著下降(P<0.05),但观察组治疗后上述指标较对照组下降更为显著(P<0.05);观察组治疗总有效率[89.17%(107/120)]较对照组[79.00%(79/100)]高,差异有统计学意义(P<0.05);2组治疗心电图、肝肾功能检查均无异常改变,仅出现轻微便秘、腹泻、上呼吸道感染、头痛等常见不良反应,观察组不良反应率[16.67%(20/120)]低于对照组[25.00%(25/100)],但2组差异无统计学意义(P>0.05)。结论西格列汀联合二甲双胍治疗老年T2DM可取得满意的血糖控制效果,且联合用药并不增加不良反应,临床疗效和安全性值得肯定。
Objective To explore the clinical efficacy and safety of sitagliptin combined with metformin in treatment of type 2 diabetes mellitus(T2DM)in elderly patients,and to provide related reference for clinical optimization treatment.Methods A total of 220 elderly patients with T2DM without severe acute and chronic complications who were treated in our hospital from June 2016 to December 2018 were enrolled in the study.According to the order of admission,the patients were divided into control group(n=100)and observation group(n=120).The patients in control group were treated byconventional drug metformin 500mg once,3 times a day,however,the patients in observation group,on the basis of control group,were treated by sitagliptin,100mg once,once a day,with a treatment course of 6 months for both grousp.The changes of fasting blood glucose(FBG),postprandial 2h blood glucose(2hPG)and glycated hemoglobin(HbA1c)before and after treatment were observed and compared between the two groups,moreover,the and the effects ofblood glucose control and the incidence of adverse reactions were also observed and compared between the two groups.Results After treatment,the levels of blood sugar indexes including FBG,2hPG,HbA1c were significantly decreased in both groups,as compared with those before treatment(P<0.05),moreover,the decrease degree in observation group was more significant than that in control group(P<0.05).The total effective rate in observation group was 89.17%(107/120),which was significantly higher than that[79%(79/100)]in control group(P<0.05).There were no abnormal changes in the electrocardiogram,liver and kidney function examination in both groups,and there were only minor adverse reactions including constipation,diarrhea,upper respiratory tract infection,headache.The adverse reaction rate in observation group was 16.67%(20/120),which was lower than that[(25%(25/100)]in control group,but there was no significant difference between the two groups(P>0.05).Conclusion The sitagliptin combined with metformin in treatment of T2DM in elderly patients can obtain satisfactory effects of blood glucose control,moreover,the combined use of the two drugs does not increase the incidence rate of adverse reactions,with reliable clinical efficacy and safety.
作者
常娟
CHANG Juan(The Fourth People’s Hospital of Hengshui City,Hebei,Hengshui 053000,China)
出处
《河北医药》
CAS
2019年第15期2332-2334,2338,共4页
Hebei Medical Journal
