摘要
长链非编码RNA(long noncoding RNA,lncRNA)是一组长度>200 nt,且不具有编码蛋白功能的RNA转录本。在表观遗传、转录、转录后水平发挥生理功能。研究发现,lncRNA参与肝脏细胞多种生命过程,并已逐渐成为慢性肝病研究的热点,包括慢性肝炎、非酒精性脂肪肝、肝纤维化、肝癌等,尤其在肝癌方面。该文根据不同慢性肝病分类,详细阐述lncRNA与慢性肝病的密切关系,总结调控机制,预测lncRNA作用新靶点,为慢性肝病的研究和防治提供研究基础和新思路。
Long noncoding RNA(lncRNA) is a group of RNA transcripts with a length of>200 nt and does not function as an encoded protein.It functions at epigenetic,transcriptional,and post-transcriptional levels.lncRNA,involved in a variety of life processes in liver cells,has gradually become a hot topic in chronic liver diseases,including chronic hepatitis,non-alcoholic fatty liver,liver fibrosis,and liver cancer,etc,especially in liver cancer.This article elaborates the close relationship between lncRNA and chronic liver disease based on the classification of different chronic liver diseases,summarizes the regulatory mechanism to predict new targets of lncRNA,and provides research basis and new ideas for the study and prevention of chronic liver disease.
作者
王志敏
金欢欢
卞勉励
开钧
杨祥
邵江娟
张峰
郑仕中
WANG Zhi-min;JIN Huan-huan;BIAN Mian-li;KAI Jun;YANG Xiang;SHAO Jiang-juan;ZHANG Feng;ZHENG Shi-zhong(Jiangsu Provincial Key Lab of Efficacy and Safety Evaluation of Chinese Materia Medica,Nanjing University of Chinese Medicine,Nanjing 210023,China;Jiangsu ProvincialKey Lab of Functional Materials for Chinese Materia Medica,Nanjing University of Chinese Medicine,Nanjing 210023,China;State Key Lab of Quality and Efficacyof Chinese Materia Medica,Nanjing University of Chinese Medicine,Nanjing 210023,China)
出处
《中国药理学通报》
CAS
CSCD
北大核心
2019年第8期1037-1040,共4页
Chinese Pharmacological Bulletin
基金
国家自然科学基金项目(No 8127054,31571455,31401210,31600653,81600483)
江苏省自然科学基金项目(No BK20140955)
江苏高校优势学科建设工程资助项目(PAPD)
