摘要
目的探讨血清鳞状上皮细胞癌抗原(SCCAg)、胃泌素释放肽前体(ProGRP)、细胞角质蛋白19片段抗原21-1(CYFRA21-1)在非小细胞肺癌(NSCLC)患者中的表达水平及诊断价值。方法选择90例NSCLC患者和90例健康体检者,分别作为观察组和对照组,检测并比较两组研究对象的血清SCCAg、ProGRP及CYFRA21-1水平,分析不同临床特征NSCLC患者的血清SCCAg、ProGRP及CYFRA21-1水平。以病理诊断结果为金标准,分析血清SCCAg、ProGRP、CYFRA21-1单独及联合检测对NSCLC的诊断价值。结果观察组患者的血清SCCAg、ProGRP及CYFRA21-1水平均明显高于对照组,差异均有统计学意义(P﹤0.01)。低分化、Ⅲ~Ⅳ期、有淋巴结转移的NSCLC患者的血清SCCAg、ProGRP及CYFRA21-1水平均明显高于高+中分化、Ⅰ~Ⅱ期、无淋巴结转移的患者,差异均有统计学意义(P﹤0.01)。血清SCCAg+ProGRP+CYFRA21-1联合诊断NSCLC的灵敏度、特异度、漏诊率、误诊率分别为88.89%、84.44%、11.11%、15.56%。结论NSCLC患者的血清SCCAg、ProGRP、CYFRA21-1水平均明显升高,且其表达水平均与患者的临床特征有关,联合检测血清SCCAg、ProGRP、CYFRA21-1水平可提高对NSCLC的诊断效能。
Objective To investigate the serum levels and diagnostic value of squamous cell carcinoma antigen(SCCAg), pro-gastrin-releasing peptide(ProGRP) and cyto-keratin 19 fragment antigen 21-1(CYFRA21-1) in patients with non-small cell lung cancer(NSCLC). Method The research included 90 patients with NSCLC and 90 healthy subjects as study group and control group, respectively, the serum SCCAg, ProGRP and CYFRA21-1 levels were measured and compared between the two groups. With pathological finding as the gold standard, the diagnostic value of each marker alone or in combination were determined. Result The serum levels of SCCAg, ProGRP and CYFRA21-1 were significantly higher in the study group than in the control group(P<0.01);poor differentiation, TNM stage Ⅲ~Ⅳ, and positive lymph node metastasis were associated with higher serum level of SCCAg, ProGRP and CYFRA21-1 as compared with high and moderate differentiation, TNM stage Ⅰ~Ⅱ, and negative lymph node metastasis, the differences were of statistical significance(P<0.01). The sensitivity, specificity, missed diagnosis rate and misdiagnosis rate of combined detection using serum SCCAg + ProGRP + CYFRA21-1 for NSCLC were 88.89%, 84.44%, 11.11%, and 15.56%, respectively.Conclusion The serum levels of SCCAg, ProGRP and CYFRA21-1 in patients with NSCLC are significantly increased,and their expression are associated with patients’ clinical characteristics, the combined detection of SCCAg, ProGRP, CYFRA21-1 improves the diagnostic efficiency for NSCLC.
作者
朱超男
陆学荣
郑贸根
王国臣
程远
ZHU Chaonan;LU Xuerong;ZHENG Maogen;WANG Guochen;CHENG Yuan(Department of Thoracic Surgery,North China University of Science and Technology Affiliated Hospital,Tangshan 063000,Hebei,China)
出处
《癌症进展》
2019年第15期1796-1799,共4页
Oncology Progress
