摘要
目的探讨利福平与硝苯地平之间的相互作用及作用机制。方法药师通过查阅中英文文献及资料,对1例合并使用利福平与硝苯地平患者的血压波动及用药情况进行分析讨论。结果利福平通过诱导CYP3A4酶活性,从而降低硝苯地平的降压作用。结论合并肺结核和高血压的患者,在抗结核和降压治疗过程中应特别关注药物的相互作用。
OBJECTIVE To explore the drug interaction between rifampicin and nifedipine,and discuss its mechanism.METHODS The blood pressure and medicines of a tuberculosis patient with hypertension were analyzed according to the record and related literatures. RESULTS Rifampicin may weaken the antihypertensive effect of nifedipine through inducing the activity of CYP3A4 enzyme. CONCLUSION Drug interaction between antihypertensive and anti-tuberculosis agents should be taken more attention.
作者
周晓雯
周美辰
钟洪兰
ZHOU Xiaowen;ZHOU Meichen;ZHONG Honglan(Department of Pharmacy, Guangzhou Chest Hospital, Guangzhou,Guangdong 510095, China)
出处
《今日药学》
CAS
2019年第7期487-489,共3页
Pharmacy Today
关键词
利福平
硝苯地平
降压药物
肝药酶
rifampicin
nifedipine
antihypertensive
hepatic enzymes
