摘要
目的观察肠炎宁颗粒联合双歧杆菌乳杆菌三联活菌片治疗小儿腹泻的临床疗效。方法选取2016年1月-2018年1月在河北省第七人民医院就诊的106例患儿作为研究对象,所有患儿随机分为对照组和治疗组,每组各53例。对照组患儿口服双歧杆菌乳杆菌三联活菌片,3次/d,年龄小于6个月的患儿1片/次,年龄大于6个月的患儿2片/次;治疗组在对照组治疗基础上口服肠炎宁颗粒,每次1/4袋,3次/d。两组患儿均治疗7 d。观察两组患者临床疗效,同时比较治疗前后两组患者临床症状改善时间、血清细胞炎性因子白细胞介素-6(IL-6)、免疫功能指标水平。结果治疗后,对照组、治疗组总有效率分别为73.58%、90.57%,两组总有效率比较差异具有统计学意义(P<0.05);治疗后,治疗组止泻时间、退热时间均明显短于对照组,两组比较差异具有统计学意义(P<0.05);治疗后,两组IL-6、免疫球蛋白G(IgG)水平均显著升高,免疫球蛋白A(IgA)水平显著降低,同组治疗前后比较差异具有统计学意义(P<0.05);且治疗后,治疗组免疫功能指标水平均明显优于对照组,两组比较差异具有统计学意义(P<0.05)。结论肠炎宁颗粒联合双歧杆菌乳杆菌三联活菌片治疗小儿腹泻具有较好的临床疗效,能改善患儿的症状和免疫功能,不良反应较少,具有一定的临床推广应用价值。
Objective To observe the clinical effect of Changyanning Granules combined with Live Combined Bifidobacterium and Lactobacillus Tablets in treatment of infantile diarrhea. Methods Children(106 cases) with infantile diarrhea in the Seventh People’s Hospital of Hebei Province from January 2016 to January 2018 were randomly divided into control and treatment groups, and each group had 53 cases. Children in the control group were po administered with Live Combined Bifidobacterium and Lactobacillus Tablets, three times daily, and 1 tablet/time for children less than 6 months and 2 tablets/time for children over 6 months. Children in the treatment group were po administered with Changyanning Granules on the basis of the control group, 1/4 bag/time, once daily.Children in two groups were treated for 7 d. After treatment, the clinical efficacy was evaluated, and the clinical improvement times,serum levels of inflammatory cytokine IL-6 and immune function in two groups before and after treatment were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 73.58% and 90.57%, respectively, and there were differences between two groups(P < 0.05). After treatment, the antidiarrheal time and antipyretic time in the treatment group were significantly shorter than those in the control group(P < 0.05). After treatment, the serum IL-6 and IgG levels in two groups were significantly decreased, but IgA levels were significantly increased, and the difference was statistically significant in the same group(P < 0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups(P < 0.05). Conclusion Changyanning Granules combined with Live Combined Bifidobacterium and Lactobacillus Tablets has clinical curative effect in treatment of infantile diarrhea, can effectively improve the symptoms and immune function of children with fewer adverse reactions, which has a certain clinical application value.
作者
宁亚灵
张玉柱
陈光营
NING Ya-ling;ZHANG Yu-zhu;CHEN Guang-ying(Department of Pediatrics, the Seventh People's Hospital of Hebei Province, Baoding 073000,China)
出处
《现代药物与临床》
CAS
2019年第7期2073-2076,共4页
Drugs & Clinic
关键词
肠炎宁颗粒
双歧杆菌乳杆菌三联活菌片
小儿腹泻
临床症状改善时间
免疫功能指标
Changyanning Granules
Live Combined Bifidobacterium and Lactobacillus Tablets
infantile Diarrhea
clinical improvement time
immune function
