摘要
表皮生长因子结构域7(epidermal growth factor-like domain-containing protein,EGFL7)是一类主要由血管内皮细胞分泌的分子,在包括胚胎发育、创伤修复、肿瘤、心血管疾病、缺血性疾病、炎症等的血管生成中发挥重要作用。本文从血管生成调控的角度,对该蛋白的表达分布特点、相关动物模型研究、血管内皮细胞相关改变、分子调控机制等进行综述,以期为相关研究及治疗提供新的思路。
Epidermal growth factor-like domain-containing protein 7(EGFL7),a member of the epidermal growth factor(EGF)-like protein family,is a potent angiogenic factor expressed in endothelial cells.The findings from present studies suggest that EGFL7 can influence different aspects related to the angiogenesis process,such as embryogenesis,tumorigenesis,wound healing,cardiovascular diseases,etc.From the point of angiogenesis regulation,we reviewed the expression profiles,animal models,endothelial phenotypes and molecular mechanisms of EGFL7,which would provide a novel insight into further researches or targeted therapies.
作者
杜仲
刘嘉靓
郑家伟
王延安
DU Zhong;LIU Jia-liang;ZHENG Jia-wei;WANG Yan-an(Department of Oromaxillofacial Head and Neck Oncology,Shanghai Ninth People's Hospital,College of Stomatology,Shanghai Jiao Tong University School of Medicine,National Clinical Research Center for Oral Diseases,Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology. Shanghai 200011,China)
出处
《中国口腔颌面外科杂志》
CAS
2019年第4期377-381,共5页
China Journal of Oral and Maxillofacial Surgery
基金
国家自然科学基金(81371164)
