摘要
目的:探讨重组人脑利钠肽(rh-BNP)预处理对急性心肌梗死(AMI)冠状动脉介入治疗(PCI)患者心肾功能及造影剂肾病发生率的影响。方法:选取2016年9月-2018年10月本院收治的96例行急诊PCI治疗的AMI患者。按照随机数字表法将其分为观察组与对照组,各48例。观察组PCI术前120 s给予rh-BNP预处理,对照组给予等量氯化钠注射液静脉滴注,比较两组手术前后心功能(LVESD、LVEDD、LVEF)、肾功能(Scr、Cys-C)及术后3 d造影剂肾病发生率。结果:术后1 d,观察组LVEF高于对照组(P<0.05);术后7 d,观察组LVESD、LVEDD均低于对照组,LVEF高于对照组,差异均有统计学意义(P<0.05);术后1、2、3 d,观察组Scr、Cys-C均低于对照组(P<0.05);观察组造影剂肾病发生率为2.08%,低于对照组的14.58%(P<0.05)。结论:直接PCI介入治疗前给予rh-BNP预处理能够有效保护AMI患者心肾功能,预防或减少造影剂肾病发生。
Objective:To investigate the effects of Recombinant Human Brain Natriuretic Peptide(rhBNP)preconditioning on cardiac and renal function and incidence of contrast-induced nephropathy in patients with acute myocardial infarction(AMI)undergoing percutaneous coronary intervention(PCI).Method:A total of96 patients with AMI treated by emergency PCI in our hospital from September 2016 to October 2018 were selected.According to the random number table method,they were divided into observation group and control group,48 cases in each group.The observation group was pretreated with rh-BNP 120 seconds before PCI,while control group was given intravenous drip of Sodium Chloride Injection.The cardiac function(LVESD,LVEDD,LVEF),renal function(Scr,Cys-C)before and after operation,and the incidence of contrast-induced nephropathy between two groups were compared.Result:After operation 1 day,the LVEF of observation group was higher than that of control group(P<0.05),after operation 7 days,the LVESD and LVEDD in observation group were lower than those of control group,LVEF was higher than that of control group,the differences were statistically significant(P<0.05).After operation 1,2 and 3 days,the Scr and Cys-C in observation group were lower than those of control group(P<0.05).The incidence of contrast-induced nephropathy was 2.08%in observation group,which was lower than 14.58%of control group(P<0.05).Conclusion:rh-BNP pretreatment before direct PCI intervention can effectively protect cardiac and renal functions of patients with AMI and prevent or reduce the occurrence of contrast-induced nephropathy.
作者
纪东华
JI Donghua(Jiamusi Central Hospital,Jiamusi 154002,China)
出处
《中国医学创新》
CAS
2019年第20期63-67,共5页
Medical Innovation of China
