摘要
目的:探讨Survivin和PCAF在食管癌中的表达及与临床病理特征之间的关系。方法:采用免疫组织化学染色法检测90例食管癌组织和40例正常组织中Survivin和PCAF的蛋白表达水平,分析其与患者临床病理特征的关系及Survivin和PCAF在食管癌中表达的相关性。结果:Survivin阳性表达在癌组织中为73.33%,明显高于正常组织的5.00%(P<0.05)。PCAF阴性表达在癌组织中为65.56%,高于在正常组织中的7.50%(P<0.05)。Survivin蛋白高表达与患者性别、年龄和肿瘤大小均无关(P>0.05),与TNM分期、肿瘤浸润深度、肿瘤分化程度和淋巴是否转移均有关(P<0.05)。PCAF的阴性表达或低表达与患者性别、年龄、TNM分期、肿瘤浸润深度、肿瘤大小以及淋巴是否转移均无关(P>0.05),与肿瘤的分化程度有关(P<0.05)。Survivin和PCAF在食管癌中的表达呈负相关(r=0.113,P<0.05)。结论:Survivin表达水平与肿瘤的分期、分化程度、浸润深度及淋巴转移均呈正相关,PCAF表达水平与肿瘤分化程度呈负相关。Survivin和PCAF在食管癌中的表达具有明显相关性,联合两者可能在食管癌的发生、发展、转移和预后等方面发挥协同作用。
Objective:To explore the relationship between Survivin and PCAF expression and clinicopathologic features in esophageal carcinoma.Method:Immunohistochemical staining was used to detect the expression of Survivin and PCAF in 90 cases of esophageal squamous cell carcinoma and 40 cases of normal esophageal carcinoma.The relationship between Survivin and PCAF expression in esophageal carcinoma and its clinicopathological features was analyzed.Result:The positive expression of Survivin was 73.33%in cancer tissues,which was significantly higher than 5.00%in normal tissues(P<0.05).The negative expression of PCAF was65.56%in cancer tissues,which was higher than 7.50%in normal tissues(P<0.05).The expression of Survivin protein was not correlated with clinicopathological features,such as sex,age and tumor size(P>0.05),but it was related with clinicopathological features,such as TNM stage,depth of tumor infiltration,tumor differentiation and lymphatic metastasis(P<0.05).There were no significant differences in the negative expression or low expression of PCAF between the sex,age,TNM stage,depth of tumor invasion,tumor size and lymphatic metastasis(P>0.05),but there was significant difference between PCAF protein and tumor differentiation(P<0.05).The expression of survivin and PCAF in esophageal carcinoma was negatively correlated(r=0.113,P<0.05).Conclusion:Survivin expression level is positively correlated with tumor stage,differentiation degree,invasion depth and lymph node metastasis,PCAF expression level is negatively correlated with tumor differentiation degree,Survivin and PCAF expression level are significantly correlated in esophageal cancer,combined with them,they may play a synergistic role in the occurrence,development,metastasis and prognosis of esophageal cancer.
作者
梁宗英
侯继申
张乐
张志民
赵宝山
孙光蕊
辛国华
LIANG Zongying;HOU Jishen;ZHANG Le(The Affiliated Hospital of Chengde Medical College,Chengde 067000,China)
出处
《中国医学创新》
CAS
2019年第20期122-126,共5页
Medical Innovation of China
基金
承德市科学技术研究与发展计划项目(201606A036)
