摘要
目的探讨宫颈癌浸润侵袭性与血管内皮生长因子(VEGF)表达水平的相关性。方法回顾性分析120例宫颈癌患者(观察组)的临床资料,同时选择120例无宫颈疾病的妇科就诊患者作为对照组。取两组患者的宫颈标本,采用免疫组化法检测VEGF表达情况。比较观察组和对照组间、有无宫颈浸润侵袭宫颈癌患者间VEGF表达阳性率的差异,分析影响宫颈癌患者VEGF表达水平的因素,以及宫颈癌患者预后与宫颈组织VEGF表达阳性细胞数的相关性。结果观察组、有浸润侵袭性宫颈癌患者的VEGF表达阳性率分别高于对照组、无浸润侵袭性宫颈癌患者(均P<0.05)。Logistic回归分析结果显示,浸润侵袭、临床分期为Ⅳ期、低分化程度为影响宫颈癌患者宫颈组织VEGF阳性表达的独立危险因素(均P<0.05)。相关分析结果显示,宫颈癌患者的术后复发率、死亡率与宫颈组织VEGF表达阳性细胞数均呈正相关(均P<0.05)。结论宫颈癌患者宫颈组织VEGF表达上调,其与宫颈癌组织的浸润侵袭性相关,或可预测患者的术后复发与死亡。
Objective To investigate the correlation of infiltration and invasion with vascular endothelial growth factor(VEGF) expression level in cervical cancer. Methods The clinical data of 120 patients with cervical cancer(observation group) were retrospectively analyzed,concurrently,120 patients without cervical disease visiting gynecology clinic as control group.The cervical specimens were collected from patients in the two groups to detect the expression of VEGF by immunohistochemistry.The positive rate of VEGF expression was compared between the observation group and the control group,or between cervical cancer patients with and without cervical infiltration and invasion,the factors influencing the VEGF expression level of patients with cervical cancer were analyzed,and the correlation of prognosis with cervical tissue VEGF expression-positive cell count was analyzed in patients with cervical cancer. Results The positive rates of VEGF expression in the observation group and cervical cancer patients with infiltration and invasion were higher than those in the control group and cervical cancer patients without infiltration and invasion,respectively (all P <0.05).Logistic regression analysis results showed that infiltration and invasion,clinical stage Ⅳ,and poor differentiation degree were independent risk factors influencing the positive expression of cervical tissue VEGF in patients with cervical cancer(all P <0.05).Correlation analysis results showed that postoperative recurrence rate and mortality positively correlated with cervical tissue VEGF expression-positive cell count in patients with cervical cancer(all P <0.05). Conclusion Up-regulation of cervical tissue VEGF expression correlates with infiltration and invasion in cervical cancer tissue,which might predict postoperative recurrence and death in the patients.
作者
刘宁宁
冯蓓
段伟
李红霞
LIU Ning-ning;FENG Bei;DUAN Wei;LI Hong-xia(Department of Oncology,Affiliated Hospital of Yan′an University,Yan′an 716000,China;Department of Gynecology,Affiliated Hospital of Yan′an University,Yan′an 716000,China)
出处
《广西医学》
CAS
2019年第13期1620-1623,共4页
Guangxi Medical Journal
基金
陕西省教育厅科学研究项目(2013JK0782)
关键词
宫颈癌
血管内皮生长因子
浸润侵袭
相关性
预后
Cervical cancer
Vascular endothelial growth factor
Infiltration and invasion
Correlation
Prognosis
