摘要
目的利用钆塞酸二钠(Gd-EOB-DTPA)增强MRI,探索肝切除术后残肝各肝段肝再生的特征。方法选取完成左半肝、右半肝切除术的肝癌合并乙肝患者共35例,其中左半肝切除术17例,右半肝切除术18例。定量分析术前4w内及术后第7d的Gd-EOB-DTPA增强MRI影像数据,比较同一手术前后各肝段之间肝-脾相对信号强度(RE)、肝细胞摄取指数(HUI)增长率的差异,并分析术前RE与HUI增长率之间的关系。结果左半肝、右半肝切除术后不同肝段之间RE、HUI增长率存在差异;肝段的术前RE与HUI增长率呈正相关(P<0.05)。结论肝癌合并乙肝患者肝切除术后,残肝各肝段的肝细胞功能及再生代偿能力存在异质性,且术后肝再生能力与术前肝细胞功能呈正相关。
Objective To explore the characteristics of residual liver regeneration after hepatectomy by Gd-EOB-DTPA-enhanced MRI. Methods A total of 35 patients who had experienced left (n=17) or right (n=18) hepatectomy due to liver cancer and hepatitis B were selected. Gd-EOB-DTPA-enhanced MRI data within four weeks before hepatectomy and on the seventh day after hepatectomy were quantitatively analyzed, so as to compare the liver-spleen relative enhancement (RE) and growth of hepatocyte uptake index (HUI) between liver segments before and after the same surgery, and analyze the relation between pre-operation RE and HUI growth. Results There was a difference in RE and HUI growth in different liver segments after right and left hepatectomy;the prevoperation RE had a positive correlation with the HUI growth (P < 0.05). Conclusion The liver cell function, compensatory and regenerative capacities in segments of the residual liver after hepatectomy in patients with liver cancer and hepatitis B vary, and there is a positive correlation between regenerative capacity after hepatectomy and liver cell function before hepatectomy.
作者
胡燕
程龙
朱永强
余前军
汪涛
Hu Yan;Cheng Long;Zhu Yongqiang;Yu Qianjun;Wang Tao(Department of Hepatobiliary Surgery, Affiliated Hospital of Southwest Medical Hospital, Luzhou,Sichuan,646000,China;Department of Hepatobiliary Surgery, General Hospital of Western Theater Command, Chengdu,Sichuan,610083,China)
出处
《西南国防医药》
CAS
2019年第8期817-819,共3页
Medical Journal of National Defending Forces in Southwest China
基金
国家自然科学基金资助项目(81300280)
四川省青年科技基金项目(2016JQ0023)
