摘要
目的观察硫酸羟氯喹联合康复新液含漱治疗糜烂型口腔扁平苔藓(EOLP)的疗效及对患者唾液中相关因子表达的影响。方法选取EOLP患者68例,按随机数字表法分为治疗组和对照组各34例。对照组口服硫酸羟氯喹治疗,治疗组在对照组治疗基础上联合康复新液含漱治疗,2组均连续治疗4周。比较2组患者治疗前后口腔疼痛情况、溃疡面积及唾液中相关因子的表达水平,统计2组治疗后临床疗效。结果自治疗前到治疗4周后2组患者VAS评分均呈下降趋势,且治疗后各个时间点治疗组VAS评分显著低于对照组(P均<0.05);自治疗前到治疗4周后2组患者口腔糜烂面积均呈缩小趋势(P均<0.05),且治疗后各个时间点治疗组明显小于对照组(P均<0.05);与治疗前比较,治疗后2组患者唾液中白蛋白(ALB)、白细胞介素-10(IL-10)水平均明显降低(P均<0. 05),且治疗组明显低于对照组(P均<0.05);治疗后2组唾液中分泌型免疫球蛋白A(IgA)、干扰素-γ(IFN-γ)水平均明显升高(P均<0.05),且治疗组明显高于对照组(P均<0.05);治疗后治疗组临床总有效率为91. 18%,显著高于对照组的58. 82%(P<0.05)。结论硫酸羟氯喹联合康复新液治疗EOLP效果显著,可有效缓解患者疼痛,促进创面愈合,与其可调节唾液中相关因子表达水平有关,值得临床推广应用。
Objective It is to investigate the curative effects of hydroxychloroquine sulfate combined with Kangfuxin solution on erosive oral lichen planus( EOLP) and the expression of related factors in saliva of patients. Methods A total of68 patients with EOLP were enrolled and were divided into treatment group and control group according to random number table,34 cases in each group. The control group was treated with hydroxychloroquine sulfate. The treatment group was treated with Kangfuxin solution on the basis of the control group. The two groups were treated continuously for 4 weeks. The oral pain,ulcer area and the expression of related factors in saliva before and after treatment were compared between the two groups. The clinical efficacy of the two groups after treatment was assessed. Results The VAS scores of the two groups were decreased from before treatment to 4 weeks after treatment,and the VAS scores of the treatment group were significantly lower than those of the control group at each time point after treatment( P < 0. 05). From before treatment to 4 weeks after treatment,the area of oral erosion in patients showed a decreasing trend,and area in the treatment group was significantly smaller than that in the control group at each time point after treatment( P < 0. 05). Compared with that before treatment,the levels of ALB and IL-10 in the saliva of the two groups were significantly lower after treatment,the levels in the group were significantly lower than the control group( P < 0. 01). The levels of Ig A and IFN-γ in the saliva of the two groups were significantly higher after treatment,and the levels in the treatment group was significantly higher than the control group( P < 0. 05). The total clinical effective rate was as high as 92. 68%,which was significantly higher than that of the control group( 58. 82%)( P < 0. 05). Conclusion Hydroxychloroquine combined with Kangfuxin solution is effective in the treatment of OLP,which can effectively alleviate the pain symptoms and promote wound healing. It is related to the regulation of the expression level of related factors in saliva,which is worthy of clinical application.
作者
王蕊
王芹
杜文斌
张慧
马赛
胥爱文
汪佳
安峰
WANG Rui;WANG Qin;DU Wenbin;ZHANG Hui;MA Sai;XU Aiwen;WANG Jia;AN Feng(The First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, Hebei, China;The Second Affiliated Hospital of Hebei North University, Zhangjiakou 075100, Hebei, China)
出处
《现代中西医结合杂志》
CAS
2019年第24期2634-2637,共4页
Modern Journal of Integrated Traditional Chinese and Western Medicine
基金
张家口市科学技术与地震局项目(1821059D)
关键词
口腔扁平苔藓
硫酸羟氯喹
康复新液
唾液
oral lichen planus
hydroxychloroquine sulfate
Kangfuxin solution
saliva
